Unraveling signaling pathway in Crohn's disease

Unraveling signaling pathway in Crohn's disease

The ectonucleotidase CD39 ultimately generates extracellular adenosine, modulating paracrine purinergic signaling. Here the authors show that IFNγ induction in CD8+ T cells is accompanied by NADH oxidase-dependent CD39 expression, which then inhibits IFNγ production in CD39-CD8+ T cells.

Interferon gamma (IFNγ)-producing CD8+ T cells (Tc1) play important roles in immunological disease.

Researchers report in the journal Nature Communications that CD3/CD28-mediated stimulation of CD8+ T cells to generate Tc1 cells, not only increases IFNγ production but also boosts the generation of reactive oxygen species (ROS) and augments expression of CD39.

Inhibition of NADPH oxidases or knockdown of gp91phox in CD8+ T cells abrogates ROS generation, which in turn modulates JNK and NFκB signalling with decreases in both IFNγ levels and CD39 expression.

CD39+CD8+ T cells substantially inhibit IFNγ production by CD39CD8+ T cells via the paracrine generation of adenosine, which is operational via adenosine type 2A receptors. Increases in numbers of CD39+CD8+ T cells and associated enhancements in ROS signal transduction are noted in cells from patients with Crohn’s disease.

These findings provide insights into Tc1-mediated IFNγ responses and ROS generation and link these pathways to CD39/adenosine-mediated effects in immunological disease.

http://www.nature.com/ncomms/2015/151109/ncomms9819/full/ncomms9819.html
Edited

Rating

Unrated
Rating:

Critical error – bailing out

This is an error that has been elevated to critical error status because it occurred during the primary error mechanism reporting system itself (possibly due to it occuring within the standard output framework). It may be masking a secondary error that occurred before this, but was never output - if so, it is likely strongly related to this one, thus fixing this will fix the other.
Unfortunately a query has failed [DELETE FROM ocp_stats WHERE date_and_time<1603846102] [Table 'ocpo1.ocp_stats' doesn't exist] (version: 9.0.20, PHP version: 5.6.40, URL: /site/index.php?page=news&type=view&id=immunology%2Funraveling-signaling)

Details here are intended only for the website/system-administrator, not for regular website users.
» If you are a regular website user, please let the website staff deal with this problem.

Depending on the error, and only if the website installation finished, you may need to edit the installation options (the info.php file).

ocProducts maintains full documentation for all procedures and tools. These may be found on the ocPortal website. If you are unable to easily solve this problem, we may be contacted from our website and can help resolve it for you.


ocPortal is a CMS for building websites, developed by ocProducts.