Researchers showed, for the first time, that a single, higher dose of vaccination to a pregnant mouse safely protects both her and her fetus from the Zika virus.
The researchers found that a single, less potent dose was not enough to protect the fetus. The findings are currently available in Nature Communications.
"Preventing birth defects in developing fetuses is an important goal of the Zika virus vaccine but studies on vaccinations in pregnant females have been lacking, raising a number of important questions that are critical to the clinical development and regulatory approval of Zika vaccines," said the senior author. "Could vaccination during pregnancy protect against infection and transmission to the fetus? Does pregnancy affect immune responses to Zika vaccination? Does maternal immunity from vaccination during pregnancy protect newborns against infection?"
The laboratory previously developed a Zika vaccine and continue studies to improve its efficacy.
In addition to protecting both mother and fetus, the researchers also learned that their live-attenuated vaccine has an excellent safety profile in pregnant female mice and her fetus. For example, they saw no adverse effects on pregnancy, fetal development or infant behavior. They also found that pregnancy weakens the mother's immune response to the vaccination, suggesting that that a higher dose of the vaccine or a more immunogenic vaccine is needed during pregnancy. Taken together, their results suggest that their vaccine may be considered for both pregnant and non-pregnant people.
https://www.utmb.edu/newsroom/article12303.aspx
https://www.nature.com/articles/s41467-019-13589-1
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fmaternal-vaccination&filter=22
A single higher dose of Zika vaccine protects both mom and fetus
- 3,348 views
- Added
Edited
Latest News
Abusive drugs hijack natura…
By newseditor
Posted 23 Apr
Mechanism of action of the…
By newseditor
Posted 23 Apr
Role of fat in rare neurolo…
By newseditor
Posted 23 Apr
How protein synthesis in de…
By newseditor
Posted 22 Apr
Atlas of mRNA variants in d…
By newseditor
Posted 22 Apr
Other Top Stories
Genetics links high blood pressure and obesity to reduced lifespan
Read more
A gene mutation enhances cognitive flexibility in mice
Read more
Inherited origin of prostate cancer in families
Read more
A gene mutation either slows or accelerates ALS
Read more
Genetic processes that determine short-sightedness
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Exploiting pancreatic cance…
By newseditor
Posted 23 Apr
Structure of antiviral drug…
By newseditor
Posted 23 Apr
Type-I-interferon-responsiv…
By newseditor
Posted 23 Apr
Selenium, diabetes, and the…
By newseditor
Posted 23 Apr
Long-term neuropsychologica…
By newseditor
Posted 23 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar