Dentists rely on composite materials to perform restorative procedures, such as filling cavities. Yet these materials, like tooth enamel, can be vulnerable to the growth of plaque, the sticky biofilm that leads to tooth decay.
In a new study, researchers evaluated a new dental material tethered with an antimicrobial compound that can not only kill bacteria but can also resist biofilm growth. In addition, unlike some drug-infused materials, it is effective with minimal toxicity to the surrounding tissue, as it contains a low dose of the antimicrobial agent that kills only the bacteria that come in contact with it.
The newly developed material published in the journal ACS Applied Materials and Interfaces is comprised of a resin embedded with the antibacterial agent imidazolium. Unlike some traditional biomaterials, which slowly release a drug, this material is non-leachable, thereby only killing microbes that touch it.
"This can reduce the likelihood of antimicrobial resistance," author said.
Researchers put the material through its paces, testing its ability to kill microbes, to prevent growth of biofilms and to withstand mechanical stress.
Their results showed it to be effective in killing bacterial cells on contact, severely disrupting the ability of biofilms to grow on its surface. Only negligible amounts of biofilm matrix, the glue that holds clusters of bacteria together, were able to accumulate on the experimental material, in contrast to a control composite material, which showed a steady accumulation of sticky biofilm matrix over time.
Then, the team assessed how much shear force was required to remove the biofilm on the experimental material. While the smallest force removed almost all the biofilm from the experimental material, even a force four times as strong was incapable of removing the biofilm from the control composite material.
"The force equivalent to taking a drink of water could easily remove the biofilm from this material," author said.
https://news.upenn.edu/news/new-dental-material-resists-plaque-and-kills-microbes-penn-dental-team-finds
http://pubs.acs.org/doi/10.1021/acsami.7b11558
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