Predicting HBV vaccine response

Predicting HBV vaccine response

Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear.

In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including one against HBV. Investigators show, using transcriptional and cytometric profiling of whole blood collected before vaccination, that heightened expression of genes that augment B-cell responses and higher memory B-cell frequencies correlate with stronger responses to HBV vaccine.

In contrast, higher levels of inflammatory response transcripts and increased frequencies of pro-inflammatory innate cells correlate with weaker responses to this vaccine.

Increased numbers of erythrocytes and the haem-induced response also correlate with poor response to the HBV vaccine.

A transcriptomics-based pre-vaccination predictor of response to HBV vaccine is built and validated in distinct sets of older adults. This moderately accurate (area under the curve65%) but robust signature is supported by flow cytometry and cytokine profiling.

This study is the first that identifies baseline predictors and mechanisms of response to the HBV vaccine.