A Phase 1 clinical trial provides promising results for a broadly neutralizing antibody (bnAb) HIV vaccine, according to a new study. The findings of this first-in-humans test establish a clinical proof-of-principal for germline-targeting vaccine design for HIV and other intractable pathogens.
A preventative HIV vaccine is urgently needed to put an end to the HIV/AIDS pandemic. One that elicits the production of broadly neutralizing antibodies (bnAbs), which can recognize the globally diverse strains of HIV and protect against infection, could provide an ideal solution.
However, triggering bnAbs through vaccination has not yet been possible. One of the key challenges towards achieving this goal is that bnAbs rarely develop during infection, and, in humans, bnAb-precursor B cells are rather uncommon. An effective bnAb HIV vaccine will need to recruit rare bnAb precursors through germline-targeting to produce HIV bnAbs.
Here, the researchers present results from a randomized, double-blind, placebo-controlled phase 1 clinical trial showing that a germline-targeting priming immunogen was safe and feasible, and induced bnAb-precursor responses in 26 of the 27 vaccine recipients (97%).
The authors designed a germline-targeting, self-assembling nanoparticle immunogen, eOD-GT8, which presented 60 copies of an engineered HIV envelope protein containing mutations designed to enhance its affinity to recruit rare bnAb precursors. “
The clinical trial reported by the researchers provides persuasive human data supporting the concept of germline targeting,” writes a researcher in a related Perspective, which discusses the study’s findings and limitations in greater detail.
https://www.science.org/doi/10.1126/science.add6502
Vaccination induces HIV broadly neutralizing antibody precursors in humans
- 1,437 views
- Added
Latest News
Complete vascularization of…
By newseditor
Posted 28 Mar
Immune cells identified as…
By newseditor
Posted 28 Mar
TB blood test which could d…
By newseditor
Posted 27 Mar
Propionate supplementation…
By newseditor
Posted 27 Mar
Role of human Kallistatin i…
By newseditor
Posted 26 Mar
Other Top Stories
Exposure to farm microbes protect against childhood asthma
Read more
Artificial intelligence to predict customized anti-cancer drug effi…
Read more
Antibody-mediated weight reduction in obese humans
Read more
Neuronal Autophagy Regulates Presynaptic Neurotransmission
Read more
Brain gene that controls food cravings, desire to exercise identified!
Read more
Protocols
Spatial proteomics in neuro…
By newseditor
Posted 28 Mar
All-optical presynaptic pla…
By newseditor
Posted 23 Mar
Epigenomic tomography for p…
By newseditor
Posted 20 Mar
A mouse DRG genetic toolkit…
By newseditor
Posted 17 Mar
An optogenetic method for t…
By newseditor
Posted 13 Mar
Publications
A microfluidic platform int…
By newseditor
Posted 28 Mar
Salmonella manipulates macr…
By newseditor
Posted 28 Mar
BHLHE40/41 regulate microgl…
By newseditor
Posted 28 Mar
Balancing neuronal activity…
By newseditor
Posted 28 Mar
OSBP-mediated PI(4)P-choles…
By newseditor
Posted 28 Mar
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar