A small peptide blocks abnormal blood vessel growth in retinal disease

A small peptide blocks abnormal blood vessel growth in retinal disease

In a new study, researcher report in the journal Science Translational Medicine that the inhibitory effect of a peptide drug called Vasotide on blood vessel overgrowth in the retinas of three animal models of human blinding retinal diseases (two rodent and one nonhuman primate).

Delivery of Vasotide in eye drops prevented a blood vessel growth-promoting molecule, VEGF, from binding to two different receptors, VEGF receptor-1 and neuropilin-1, expressed by the retinal endothelial cells that line the inner surface of blood vessels.

http://stm.sciencemag.org/content/7/309/309ra165
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