Human visual cortex holds neurons that selectively respond to intermediate colors

Human visual cortex holds neurons that selectively respond to intermediate colors

It was previously believed that the human visual system encoded color information through combinations of four opponent colors - red/green, yellow/blue - and dark/light components. In this format, orange can be represented as the combination of red and yellow, and purple as a combination of blue and red.

However, recent electrophysiological studies in primates have revealed the presence of neurons in the visual cortex, each of which are selective to intermediate color.

Studies using human participants - through psychophysical and brain-activity-imaging techniques - have also shown indirect evidence of the presence of those neurons, although no direct recording of hue-selective response has yet been made, and the variability and population of neurons selective to intermediate colors have not been reported explicitly in humans.

The research group succeeded in recording neuronal responses selective to intermediate hues in human brains by using a functional MRI technique.

During the measurement of brain activity, subjects were shown a circular checkered pattern which gradually changed its color along a hue circle (Figure: right panel, outer ring). The study was done under an equal light intensity carefully adjusted beforehand in each subject.

The time course of brain activity was analyzed for each pixel (voxel) of the fMRI data (Top Figure : left panel). For example, if the response of a voxel was dominated by neurons selective to a particular hue, it would exhibit a maximum response when the selective hue is presented.

The results were summarized, in terms of the voxel count selective to each hue direction, as histograms. An example of averaged histograms for the primary visual cortex (V1: one of four brain regions measured in the study) is shown in the figure (Top Figure: right panel). The study's results also confirmed that the cortical responses selective to intermediate hues are not just the combined responses of the four opponent hues.

This is the first report in the world, of the histogram of neurons selective to each hue, including intermediate hues, in human subjects. Full findings of the study will appear in the scientific journal Cerebral Cortex.