The depression is treated with most common of these drugs,
such as Prozac and Lexapro, are selective serotonin reuptake
inhibitors, or SSRIs. Unfortunately, SSRIs are effective in
only a third of patients with depression. In addition, even
when these drugs work, they typically take between three and
eight weeks to relieve symptoms. As a result, patients often
suffer for months before finding a medicine that makes them
feel better.
Scientists identified promising compounds that could
successfully treat depression in less than 24 hours while
minimizing side effects. The research was published this
month in the journal Neuropsychopharmacology and yet to
be tested in people.
The researchers tested the compounds in rats that were
subjected to chronic mild stress that caused the animals to act
in ways that resemble human depression. Giving stressed rats
GABA-NAMs successfully reversed experimental signs of a
key symptom of depression, anhedonia, or the inability to feel
pleasure.
Remarkably, the beneficial effects of the compounds appeared
within 24 hours - much faster than the multiple weeks needed
for SSRIs to produce the same effects.In tests on the rats' brains, the researchers found that the compounds rapidly increased the strength of excitatory communication in regions that were weakened by stress and are thought to be weakened in human depression. No effects of the compound were detected in unstressed animals, raising hopes that they will not produce side effects in human patients.
http://somvweb.som.umaryland.edu/absolutenm/templates/? a=3157&z=41
Edited
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