An international research team has identified a system of communication networks that exists among organs and tissues that regulate metabolism. Findings from their study provide, for the first time, a detailed "atlas" illustrating how the body creates and uses energy, and how imbalances in the networks may impact overall health.
Published in the journal Cell, the research reveals the highly coordinated, multi-tissue metabolism underlying the body's circadian rhythms and examines how disruptions in these rhythms - such as those caused by high-fat diets - induce misalignment among the network clocks and can trigger inflammation, which has been linked to major diseases and can affect lifespan.
Lead author first showed the circadian rhythm-metabolism link some 10 years ago, identifying the metabolic pathways through which circadian proteins sense energy levels in cells.
The researchers examined a variety of genetic clocks - ranging from those in blood serum, the liver and muscle to those in the brain's prefrontal cortex and hypothalamus, as well as in brown and white body fat. The resultant atlas maps the connections among various organs and tissues, which together make up the so-called body clock that governs day-night patterns of metabolic activity. The team then tested the connections to see how a high-fat diet in mice scrambled the body's fine-tuned metabolic patterns and rewired the communication and coordination among clocks.
"The effects of the high-fat diet give evidence that external factors can disrupt the coordinated metabolic pattern," the author said, adding that with this atlas, information from one organ or tissue group can provide a systemwide understanding of metabolic irregularities and the illnesses related to them.
"We can now create an approach to personalized medicine based on an individual's circadian metabolism," the author said. "Metabolic profiling is a big-data method of optimizing metabolic health."
Body clock connects and co-ordinates genetic clock among organs and tissues
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