Researchers have discovered a safe and effective novel therapy to reduce insulin requirements and hypoglycemic episodes in adult subjects with recent onset Type 1 diabetes by promoting the patient's own beta cell function and insulin production -- the first such discovery to target diabetes in this manner.
The findings, published by Nature Medicine, reveal that regular oral administration of verapamil, a common blood pressure medication first approved for medical use in 1981, enabled patients to produce higher levels of their own insulin, limiting their need for insulin injections to balance out their blood sugar levels.
The randomized, double-blind, placebo-controlled human trial identified verapamil as a safe, effective, and promising therapy -- a groundbreaking finding in the field of diabetes research.
"The data collected from our clinical trial gives us every indication to believe that individuals with Type 1 diabetes have the promise of a treatment approach that would reduce their external insulin requirements and improve their blood sugar control and quality of life, thanks to the effects that verapamil has in promoting the body's own beta cell function," said the principal investigator of the trial. "While this research is not an end-all cure for Type 1 diabetes, these findings are getting us closer to disease-altering therapies that can enable individuals with Type 1 diabetes to have more control over their disease and maintain some of their body's own insulin production."
In 2014, the lab discovered that verapamil completely reversed Type 1 diabetes in animal models and sought to test the effects of the drug in human subjects in a clinical trial, funded by a $2.1 million grant from the JDRF. Verapamil has been Food and Drug Administration approved and available for prescription for the treatment of high blood pressure for more than three decades. However, this research marks the first time that the drug has been tested for safety and efficacy in treating Type 1 diabetes.
Type 1 diabetes occurs as the result of one's immune system attacking the beta cells in the pancreas that produce insulin to regulate and maintain optimal blood sugar levels. When beta cells are being destroyed, a person's ability to produce insulin declines, causing blood sugar levels to rise and making the person more and more dependent on external insulin. The clinical trial discovered that when a patient takes verapamil, beta cell function is preserved, enabling the body to produce more of its own insulin. This lessened the clinical trial participants' reliance on external insulin, which all individuals with Type 1 diabetes must have to effectively regulate their blood sugar levels.
The verapamil clinical trial monitored 24 patients age 18 to 45, each over the course of one year. Eleven patients received verapamil and 13 received placebo. All clinical trial participants were diagnosed with Type 1 diabetes within three months of their start in the trial and continued with their prescribed insulin pump therapy throughout the duration of the study. Researchers monitored the placebo and verapamil groups' total daily dose of insulin, the amount of insulin produced, the percent change in insulin production, and their HbA1C levels. In addition, the number of hypoglycemic events that the patients experienced were recorded, and the percent of time each patient registered in healthy blood glucose ranges were analyzed using a continuous glucose monitoring system.
"Although this is a smaller sample group, our trial results give us promise that subjects with Type 1 diabetes have therapy options and that we are nearing a more effective way to deal with this disease," said co-principal investigator of the study. "Beyond verapamil allowing subjects with Type 1 diabetes the ability to live a life with less external insulin dependence, these findings will impact the quality of life that they can have. Hopefully, by improving overall blood sugar control it will also limit their risks for other comorbidities, including heart attack, blindness, kidney disease, and more."
While this study specifically addressed findings in adult subjects diagnosed within three months of the trial's start, principal investigator notes that future long-term studies are needed to help determine the effect of verapamil on both the pediatric Type 1 diabetes population, and individuals with Type 1 diabetes who have been living with and/or diagnosed with the disease longer than three months. Furthermore, verapamil's effects on Type 2 diabetes have not been tested or studied in prospective controlled trials; principal investigator said and future studies that explore the potential for this regimen to positively impact Type 2 diabetes are therefore also needed. However, in mouse models of Type 2 diabetes and in recent epidemiological studies verapamil use has been associated with lower risk of developing Type 2 diabetes and with better blood sugar control.
http://www.uab.edu/news/research/item/9585-human-clinical-trial-reveals-verapamil-as-an-effective-type-1-diabetes-therapy
https://www.nature.com/articles/s41591-018-0089-4
Edited
Latest News
Metabolic rewiring promotes…
By newseditor
Posted 18 Apr
A drug to prevent flu-induc…
By newseditor
Posted 18 Apr
New origin of deep brain waves
By newseditor
Posted 17 Apr
Starving cells hijack prote…
By newseditor
Posted 17 Apr
Miniature battery-free epid…
By newseditor
Posted 17 Apr
Other Top Stories
Using E. coli to detect hormone disruptors in the environment
Read more
Remote-controlled bacteria made to swim
Read more
Optogenetic tool that inhibits neural activity
Read more
Microscopic submarines for your stomach
Read more
Artificial skin that 'feels' temperature changes created!
Read more
Protocols
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Modular dual-color BiAD sen…
By newseditor
Posted 31 Mar
Publications
How does the microbiota con…
By newseditor
Posted 18 Apr
The integrated stress respo…
By newseditor
Posted 18 Apr
The immunobiology of herpes…
By newseditor
Posted 17 Apr
Circulating microbiome DNA…
By newseditor
Posted 17 Apr
Spindle oscillations in com…
By newseditor
Posted 17 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar
Critical error – bailing out
Details here are intended only for the website/system-administrator, not for regular website users.
» If you are a regular website user, please let the website staff deal with this problem.
Depending on the error, and only if the website installation finished, you may need to edit the installation options (the info.php file).
ocProducts maintains full documentation for all procedures and tools. These may be found on the ocPortal website. If you are unable to easily solve this problem, we may be contacted from our website and can help resolve it for you.
ocPortal is a CMS for building websites, developed by ocProducts.