Adipocyte dysfunction is directly associated with pathologies characterized by metabolic disorders including obesity, diabetes mellitus type II and metabolic syndrome. Adipogenesis is a complex process that has been extensively studied in different cell models.
The main contributions in this area have been elucidating the signaling pathways that regulate adipogenic differentiation from pre-adipocytes to mature adipocytes. Cells resulting from this process are generally characterized by a spherical morphology with the presence of fat droplets in their cytoplasm. These parameters have been considered as the cellular events that determine the final stage of adipogenesis.
However functionality and maturity of the differentiated adipocytes have been sparsely explored. In this context, and considering that adipose tissue plays a central role in energy homeostasis, assessing the function of differentiated adipocytes is an important parameter to considerer in the study of the adipogenesis.
In a study reported in the journal Experimental Biology and Medicine researchers demonstrate that exposure of mesechymal stromal cells (MSCs) to a simple adipogenic stimulus consisting of dexamethasone and rosiglitazone (D&R) induces adipogenic differentiation.
They observed that a significant percentage of these cells differentiate into adipogenic lineage, characterized not only by the presence of fat droplets, but also by the loss of proliferative potential, expression of genes characteristic of a mature adipocyte, sensitivity to insulin and synthesis and secretion of adipokines.
This evidence is relevant especially considering that the standard adipogenic cocktail widely used to induce the adipogenic process in MSCs, generates non-functional immature adipocytes.
http://ebm.sagepub.com/content/240/9/1235
Edited
Latest News
Brain hormone regulate both…
By newseditor
Posted 17 Mar
Blocking long non-coding RN…
By newseditor
Posted 17 Mar
Artificial intelligence and…
By newseditor
Posted 17 Mar
Blood-brain barrier protein…
By newseditor
Posted 17 Mar
Preventing heart attacks an…
By newseditor
Posted 17 Mar
Other Top Stories
Loneliness is a heritable trait?
Read more
How memories form in real time
Read more
How brain separates relevant and irrelevant information
Read more
Link between chronic pain and lack of sleep
Read more
Smoking has long lasting impact on human genome
Read more
Protocols
Integration of Kupffer cell…
By newseditor
Posted 18 Mar
A mouse DRG genetic toolkit…
By newseditor
Posted 17 Mar
An optogenetic method for t…
By newseditor
Posted 13 Mar
Profiling native pulmonary…
By newseditor
Posted 08 Mar
Neuromuscular organoids mod…
By newseditor
Posted 06 Mar
Publications
Synaptopathy: presynaptic c…
By newseditor
Posted 18 Mar
Allergic Rhinitis
By newseditor
Posted 18 Mar
ALK upregulates POSTN and W…
By newseditor
Posted 18 Mar
PRODH safeguards human naiv…
By newseditor
Posted 18 Mar
Secretin-dependent signals…
By newseditor
Posted 17 Mar
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar