Staphylococcus epidermidis is an ubiquitous colonizer of healthy human skin, but it is also a notorious source of serious nosocomial infections with indwelling devices and surgical procedures such as hip replacements.
It has not been known whether all members of the S. epidermidis population colonizing the skin asymptomatically are capable of causing such infections, or if some of them have a heightened tendency to do so when they enter either the bloodstream or a deep tissue.
By combining large-scale population genomics and in vitro measurements of immunologically relevant features of these bacteria, they were able to use machine learning to successfully predict the risk of developing a serious, and possibly life-threatening infection from the genomic features of a bacterial isolate.
Authors identify 61 genes containing infection-associated genetic elements that correlate with in vitro variation in known pathogenicity traits (biofilm formation, cell toxicity, interleukin-8 production, methicillin resistance). Horizontal gene transfer spreads these elements, allowing divergent clones to cause infection.
Finally, Random Forest model prediction of disease status (carriage vs. infection) identifies pathogenicity elements in 415 S. epidermidis isolates with 80% accuracy, demonstrating the potential for identifying risk genotypes pre-operatively.
This opens the door for future technology where high-risk genotypes are identified proactively when a person is to undergo a surgical procedure, which has high potential to reduce the burden of nosocomial infections caused by S. epidermidis.
https://www.helsinki.fi/en/news/science-news/safe-hip-replacements-building-an-ai-to-predict-if-you-carry-a-killer-on-your-skin
https://www.nature.com/articles/s41467-018-07368-7
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fdisease-associated&filter=22
Artificial Intelligence to detect infectious bacterial on the skin
- 982 views
- Added
Edited
Latest News
Abusive drugs hijack natura…
By newseditor
Posted 23 Apr
Mechanism of action of the…
By newseditor
Posted 23 Apr
Role of fat in rare neurolo…
By newseditor
Posted 23 Apr
How protein synthesis in de…
By newseditor
Posted 22 Apr
Atlas of mRNA variants in d…
By newseditor
Posted 22 Apr
Other Top Stories
Childhood stress matures brain early!
Read more
Two spindle formation before the first cell division!
Read more
Environmentally sensitive DNA methylation states in the very early…
Read more
How separating child from mother could derail brain development
Read more
How maternal and paternal chromosomes get along after fertilization?
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Exploiting pancreatic cance…
By newseditor
Posted 23 Apr
Structure of antiviral drug…
By newseditor
Posted 23 Apr
Type-I-interferon-responsiv…
By newseditor
Posted 23 Apr
Selenium, diabetes, and the…
By newseditor
Posted 23 Apr
Long-term neuropsychologica…
By newseditor
Posted 23 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar