Researchers have injected brilliant tracer molecules into the blood of mice and demonstrated that they can then visualize protein clots in the mice's brain for up to six weeks. Such lumps of protein, or aggregates, of various proteins such as amyloid-beta and tau, are a hallmark of Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions in which the nerve cells die.
There are still many question marks about why some proteins sometimes clump together and over time form plaques in the brain. Therefore, the research community has a great need for tools to follow the process. And here the time aspect is central.
Using the tracer molecules that have been there before, researchers can get snapshots of the amount of plaque in the brain at a specific time. Thanks to the new tracer molecules, the researchers see the signal for a long time and that opens up new possibilities for research on neurodegenerative diseases.
The biggest advantage we see in this study in mice is that one could use the tracer molecules to study in real time how protein aggregates are formed. Among other things, researchers could investigate when neurons in the process begin to die due to protein aggregates, says the senior author.
In the study, published in the journal Acta Neuropathologica Communications , the researchers saw how the tracer molecules colored in newly formed protein clumps as the protein aggregates were formed
In the study we also show that if we use two tracer molecules at the same time, we can see different types of aggregates of amyloid-beta, and not just the total amount of protein aggregates. This has not been seen before in living mice, says the author.
Previously, researchers have found various forms of amyloid aggregates in brain tissue from deceased people with Alzheimer's disease. They suspect that several different types of aggregates are involved in the disease course.
The authors hope that the tracer molecules will eventually be used in diagnostics in healthcare. But there it is some distance left. In living people, it is not possible to use the same way to visualize where in the brain the tracer molecules have bound to protein aggregates. The researchers therefore want to adapt the tracer molecules so that they can be detected in a way that is used in healthcare today. In collaboration, they will link radioactive isotopes to the molecules, making it possible to see them with PET (positron emission tomography) camera.
If we can start using these tracer molecules in patients, I think the first step will be to use the tracer molecules in clinical trials to monitor the effect of various potential treatments. An interesting question to look at is whether different treatments affect different forms of protein aggregates, says the author.
https://liu.se/nyhet/nya-mojligheter-att-forsta-alzheimers-sjukdom
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-019-0832-1
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fin-vivo-detection-of&filter=22
In vivo detection of tau fibrils and amyloid β aggregates with tracers
- 1,564 views
- Added
Edited
Latest News
Abusive drugs hijack natura…
By newseditor
Posted 23 Apr
Mechanism of action of the…
By newseditor
Posted 23 Apr
Role of fat in rare neurolo…
By newseditor
Posted 23 Apr
How protein synthesis in de…
By newseditor
Posted 22 Apr
Atlas of mRNA variants in d…
By newseditor
Posted 22 Apr
Other Top Stories
A new role for chaperone, Hsp90
Read more
Molecular details of CRISPR-Cas9 RNA editing technology
Read more
Cutaneous gene therapy to treat cocaine overdose
Read more
The mechanism protecting replicated DNA from degradation
Read more
Nobel Prize for Chemistry goes to "directed evolution of enzymes an…
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Exploiting pancreatic cance…
By newseditor
Posted 23 Apr
Structure of antiviral drug…
By newseditor
Posted 23 Apr
Type-I-interferon-responsiv…
By newseditor
Posted 23 Apr
Selenium, diabetes, and the…
By newseditor
Posted 23 Apr
Long-term neuropsychologica…
By newseditor
Posted 23 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar