Manipulating brain cells using smartphone

Manipulating brain cells using smartphone


A team of scientists have invented a device that can control neural circuits using a tiny brain implant controlled by a smartphone.

Researchers, publishing in Nature Biomedical Engineering, believe the device can speed up efforts to uncover brain diseases such as Parkinson's, Alzheimer's, addiction, depression, and pain.

The device, using Lego-like replaceable drug cartridges and powerful bluetooth low-energy, can target specific neurons of interest using drug and light for prolonged periods.

"The wireless neural device enables chronic chemical and optical neuromodulation that has never been achieved before," said lead author.

The author said this technology significantly overshadows conventional methods used by neuroscientists, which usually involve rigid metal tubes and optical fibers to deliver drugs and light. Apart from limiting the subject's movement due to the physical connections with bulky equipment, their relatively rigid structure causes lesion in soft brain tissue over time, therefore making them not suitable for long-term implantation. Though some efforts have been put to partly mitigate adverse tissue response by incorporating soft probes and wireless platforms, the previous solutions were limited by their inability to deliver drugs for long periods of time as well as their bulky and complex control setups.

To achieve chronic wireless drug delivery, scientists had to solve the critical challenge of exhaustion and evaporation of drugs. Researchers collaborated to invent a neural device with a replaceable drug cartridge, which could allow neuroscientists to study the same brain circuits for several months without worrying about running out of drugs.

These 'plug-n-play' drug cartridges were assembled into a brain implant for mice with a soft and ultrathin probe (thickness of a human hair), which consisted of microfluidic channels and tiny LEDs (smaller than a grain of salt), for unlimited drug doses and light delivery.

Controlled with an elegant and simple user interface on a smartphone, neuroscientists can easily trigger any specific combination or precise sequencing of light and drug deliveries in any implanted target animal without need to be physically inside the laboratory. Using these wireless neural devices, researchers could also easily setup fully automated animal studies where behavior of one animal could positively or negatively affect behavior in other animals by conditional triggering of light and/or drug delivery.

"This revolutionary device is the fruit of advanced electronics design and powerful micro and nanoscale engineering," said the senior author. "We are interested in further developing this technology to make a brain implant for clinical applications."

https://www.nature.com/articles/s41551-019-0432-1

https://www.nature.com/articles/s41551-019-0432-1

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