New neuroelectronic system can read and modify brain circuits

New neuroelectronic system can read and modify brain circuits


As researchers learn more about the brain, it has become clear that responsive neurostimulation is becoming increasingly effective at probing neural circuit function and treating neuropsychiatric disorders, such as epilepsy and Parkinson's disease. But current approaches to designing a fully implantable and biocompatible device able to make such interventions have major limitations: their resolution isn't high enough and most require large, bulky components that make implantation difficult with risk of complications.

An Engineering team has come up with a new approach that shows great promise to improve such devices. Building on their earlier work to develop smaller, more efficient conformable bioelectronic transistors and materials, the researchers orchestrated their devices to create high performance implantable circuits that enable allow reading and manipulation of brain circuits. Their multiplex-then-amplify (MTA) system requires only one amplifier per multiplexer, in contrast to current approaches that need an equal number of amplifiers as number of channels.

"It is critical to be able to detect and intervene to treat brain-disorder-related symptoms, such as epileptic seizures, in real time," said the senior author. "Not only is our system much smaller and more flexible than current devices, but it also enables simultaneous stimulation of arbitrary waveforms on multiple independent channels, so it is much more versatile.

The study was published in Proceedings of the National Academy of Sciences (PNAS).

In order to record, detect, and localize epileptic discharges, scientists must log brain activity in multiple locations with high temporal resolution. This requires a high-sampling-rate multi-channel acquisition and stimulation device and circuit. Conventional circuits need an equal number of amplifying circuits as number of channels before they can combine these signals into a stream of data using multiplexing. This increases the size of the circuits linearly with the number of channels.

As the team continued to make their electrodes more effective, lowering impedance by using a conducting polymer, they suddenly wondered what would happen if they took advantage of their electrode improvements in circuit design and placed the multiplexer in front of, rather than after, the amplifier.

With this new idea in mind, the team built the MTA device and then confirmed its functionality by developing a fully implantable, responsive embedded system that can acquire--in real time--individual neural action potentials using conformable conducting polymer-based electrodes. It can accomplish this with low-latency arbitrary waveform stimulation and local data storage--all within a miniaturized (approximately the size of a quarter) physical footprint.

"The key challenge was to create an electric-charge drainage path during the multiplexing operation to eliminate any unwanted charge accumulation," said the first author of the study.

The MTA device, which was fabricated at the Columbia Nano-Initiative, enabled the team to then develop a novel closed-loop protocol to suppress pathological coupling between the hippocampus and cortex in real-time within an epileptic network. This type of approach could help address memory problems that often accompany epilepsy.

"These devices will allow application of targeted high-spatiotemporal resolution responsive neurostimulation approaches to a variety of brain functions, greatly broadening our ability to chronically modify neural networks and treat neuropsychiatric disease," the author said.

The team is now integrating their system with various experimental platforms with the goal of improving neural network function and cognitive skills.

https://www.pnas.org/content/118/20/e2022659118

http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fresponsive-manipulation&filter=22

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