Precisely timed brain stimulation improves memory

Precisely timed brain stimulation improves memory

Precisely timed electrical stimulation to the left side of the brain can reliably and significantly enhance learning and memory performance by as much as 15 percent, according to a study published in Nature Communications. It is the first time such a connection has been made and is a major advance toward the goal of Restoring Active Memory.

"Our study has two novel aspects," said lead author on the paper. "We developed a system to monitor brain activity and trigger stimulation responsively based on the subject's brain activity. We also identified a novel target for applying stimulation, the left lateral temporal cortex."

In previous work electrical pulses were delivered at regular intervals, independent of a subject's success at learning. For example, during a free-recall memory task, researchers presented words on a screen for the patient to learn, and they applied brain stimulation with every other word in an effort to improve the outcome. In this case, the stimulation was not in response to specific brain-activity patterns.

In the current study, they took a different tack, one that included monitoring a patient's brain activity in real time during a task. As the patient watched and attempted to absorb a list of words, a computer tracking and recording brain signals would make predictions based on those signals and then prompt an electrical pulse, at safe levels and unfelt by the participants, when they were least likely to remember the new information.

"During each new word the patient viewed, the system would record and analyze brain activity to predict whether the patient had learned it effectively. When the system detected ineffective learning, that triggered stimulation, closing the loop," lead author said.

After stimulation was turned off, the system would again listen to the subject's brain activity, waiting for the next appropriate opportunity to generate the pulse.

The study involved 25 neurosurgical patients receiving treatment for epilepsy. All subjects had already had electrodes implanted in their brains as part of routine clinical treatment for epilepsy.

To build the models that used brain activity to make predictions, each participant performed the free-recall memory task during at least three 45-minute sessions before the team introduced any closed-loop stimulation; multiple sessions increased the confidence that the brain activity linked to ineffective learning reflected a true pattern rather than an accidental blip. Patients then took part in at least one session involving brain stimulation.

"By developing patient-specific, personalized, machine-learning models," senior author said, "we could program our stimulator to deliver pulses only when memory was predicted to fail, giving this technology the best chance of restoring memory function. This was important because we knew from earlier work that stimulating the brain during periods of good function was likely to make memory worse."

With this finding, the four-year project comes closer to a fully implantable neural monitoring and stimulation system. The researchers said they believe there is great potential for the therapeutic benefits of this stimulation, particularly for people with traumatic brain injury and Alzheimer's disease.

"Now we know more precisely," author said, "where to stimulate the brain to enhance memory in patients with memory disorders, as well as when to stimulate to maximize the effect."

https://news.upenn.edu/news/penn-researchers-prove-precisely-timed-brain-stimulation-improves-memory

https://www.nature.com/articles/s41467-017-02753-0

Edited

Rating

Unrated
Rating: