Cell motility is a phenomenon, where cells move by protruding and contracting sections of the membrane. This is a complex process performed through sophisticated balancing act between internal cytoskeleton structure and the cell membrane proteins. Cancer cells are known to be abnormally flexible than the healthy cells, primarily due to their inherent weak structures. The forces between the cytoskeleton and the cell surface proteins are different between cancerous and healthy cells. The surface receptors are also abnormally many more on the surface of cancer cells.
Researchers have demonstrated a novel cancer cell detection method based on real time cell behavior tracking on engineered surfaces. A synthetic RNA molecule is coated on chip surface to identify cancer cells. The otherwise "calm and quiet" cells on this surface show interesting dancing behavior when their membrane receptors are matched to the surface RNA molecules.
The behavior is quantified using interesting image processing techniques. Cancer cells are shown to demonstrate significantly different behavior than regular healthy cells. The human glioblastoma (hGBM) cells thus showed distinctly enhanced cell movements and activity on the RNA functionalized chips.
This phenomenon has potential to detect cancer in a tabletop setup thus leveraging doctors to perform frequent and economic tests with faster results and better disease prediction. The report appears in the journal TECHNOLOGY.