Extracellular vesicle cargo in cancer
Extracellular vesicles reflect cancer complexity.
Reduced costs in omics technologies allow for multimodal, comprehensive profiling of extracellular vesicle cargo, even though extracellular vesicle multiomics studies still face methodological constraints.
Recent extracellular vesicle multi-omics studies primarily focus on proteomic and transcriptomic data combinations, with a primary focus on biomarker applications.
Extracellular vesicle (epi-)genomics is not readily performed due to low extracellular vesicle-DNA recovery.
Integration of different extracellular vesicle omics datasets relies on cellular systems for interpretation, which constrains relevance.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(26)00131-7
