Dr. Alan G. Goodman
Assistant Professor,
Washington State University, Pullman, WA
Hangout Title: Conservation of Host-pathogen Interactions and Innate Immunity in Insects and Mammals
Hangout Schedule: Dec 18th: 11 am CST, 12 pm EST, 9 am PST, 10.30 pm IST
Research & Interests
Our research focuses on the immune response to pathogenic infection. In addition to experimental laboratory techniques, we utilize mammalian and invertebrate animals models along with mathematical modeling and high-throughput computational analyses to further understand the cellular signaling pathways during infection. The complementary use of these techniques across multiple animal models will guide us to better therapeutically intervene during autoimmune, microbial, and vector-borne disease.
Together, our research uses orthogonal animal models along with experimental and computational techniques to identify, characterize, and describe molecular mechanisms of pathogenic infection. We benefit from exciting interdisciplinary and collaborative efforts that motivate the pursuit of improving human health.
PUBLICATIONS
Bastos RG, Howard ZP, Hiroyasu A, Goodman AG.
Host and bacterial factors control susceptibility of Drosophila melanogaster to Coxiella burnetii infection.
Infect. Immun. 2017 July; 85(7): e00218-17.
PMID: 28438980
Ahlers LRH, Bastos RG, Hiroyasu A, Goodman AG.
Invertebrate iridescent virus 6, a DNA virus, stimulates a mammalian innate immune response through RIG-I-like receptors.
PLoS One. 2016 Nov 8; 11(11): e0166088.
PMID: 22615208
Ahlers LRH, Goodman AG.
Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity.
Curr. Clin. Microbiol. Rpt. 2016 Sep; 3(3): 132-41.
PMID: 27857881
Vijayan A, Gómez CE, Espinosa DA, Goodman AG, Sanchez-Sampedro L, Soranzo COS, Zavala F, Esteban M.
Adjuvant-like effect of vaccinia virus 14K protein: a case study with malaria vaccine based on the circumsporozoite protein.
J. Immunol. 2012 Jun 15; 188(12): 6407-17.
PMID: 22615208
Goodman AG, Heinen PP, Guerra S, Vijayan A, Sorzano COS, Gomez CE, Esteban M.
A human multi-epitope recombinant vaccinia virus as a universal T-cell vaccine candidate against influenza virus.
PLoS One. 2011 Oct 5; 6(10): e25938.
PMID: 21998725
Goodman AG, Tanner BCW, Chang ST, Esteban M, Katze MG.
Virus infection rapidly activates the P58IPK pathway, delaying peak kinase activation to enhance viral replication.
Virology. 2011 Aug 15; 417(1): 27-36.
PMID: 21612809
Cillóniz C, Pantin-Jackwood M, Ni C, Goodman AG, Peng X, Proll SC, Carter VS, Rosenzweig ER, Szretter KJ, Katz JM, Korth MJ, Swayne DE, Tumpey TM, Katze MG.
Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection.
J. Virol. 2010 Aug; 84(15): 7613-24.
PMID: 20504916
Datta R, Shah GN, Rubbelke TS, Waheed A, Rauchman M, Goodman AG, Katze MG, Sly WS.
Progressive renal injury from transgenic expression of human carbonic anhydrase IV folding mutants is enhanced by deficiency of p58IPK.
Proc. Natl. Acad. Sci. USA. 2010 Apr 6; 107(14): 6448-52.
PMID: 20308551
Goodman AG, Zeng H, Proll SC, Peng X, Cillóniz C, Carter VS, Korth MJ, Tumpey TM, Katze MG.
The alpha/beta interferon receptor provides protection against influenza virus replication but is dispensable for inflammatory response signaling.
J. Virol. 2010 Feb; 84(4): 2027-37.
PMID: 19939913
Goodman AG, Fornek JL, Medigeshi GR, Perrone LA, Peng X, Dyer MD, Proll SC, Knoblaugh SE, Carter VC, Korth MJ, Nelson JA, Tumpey TT, Katze MG.
P58IPK: a novel “CIHD” member of the host innate defense response against pathogenic virus infection.
PLoS Pathog. 2009 May; 5(5): e1000438.
PMID: 19461876
Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman, RJ, Hegde RS.
The role of P58IPK in protecting the stressed endoplasmic reticulum.
Mol. Biol. Cell. 2007 Sep; 18(9): 3681-3691.
PMID: 17567950
Goodman AG, Smith JA, Balachandran S, Perwitasari O, Proll SC, Thomas MJ, Korth MJ, Barber GN, Schiff LA, Katze MG.
The cellular protein, P58IPK, regulates influenza virus mRNA translation and replication through a PKR mediated mechanism.
J. Virol. 2007 Mar; 81(5): 2221-2230.
PMID: 17166899
Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D.
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload.
Cell. 2006 Aug 25; 126(4):727-39.
PMID: 16923392
Kash JC, Goodman AG, Korth MJ, Katze MG.
Hijacking of the host-cell response and translational control during influenza virus infection.
Virus Res. 2006 Jul; 119(1):111-20. Review.
PMID: 16630668
Goodman A, Tseng Y, Wirtz D.
Effect of length, topology, and concentration on the microviscosity and microheterogeneity of DNA solutions.
J. Mol. Biol. 2002 Oct 18;323(2):199-215.
PMID: 12381315
Franco AA, Cheng RK, Goodman A, Sears CL.
Modulation of bft expression by the Bacteroides fragilis pathogenicity island and its flanking region.
Mol Microbiol. 2002 Aug; 45(4): 1067-77.
PMID: 12180925
Ladiges WC, Knoblaugh SE, Morton JF, Korth MJ, Sopher BL, Baskin CR, MacAuley A, Goodman AG, LeBoeuf RC, Katze MG.
Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK.
Diabetes. 2005 Apr;54(4):1074-81.
PMID: 15793246
Billharz R, Zeng H, Proll SC, Korth MJ, Lederer S, Albrecht R, Goodman AG, Rosenzweig E, Tumpey TM, García-Sastre A, Katze MG.
The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways.
J. Virol. 2009 Oct; 83(20): 10557-70.
PMID: 19706713
Ahlers LRH, Goodman AG.
Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity.
Curr. Clin. Microbiol. Rpt. 2016 Sep; 3(3): 132-41.
PMID: 27857881
Ahlers LRH, Bastos RG, Hiroyasu A, Goodman AG.
Invertebrate iridescent virus 6, a DNA virus, stimulates a mammalian innate immune response through RIG-I-like receptors.
PLoS One. 2016 Nov 8; 11(11): e0166088.
PMID: 22615208
