Dr. Nikos Tapinos MD, PhD

Associate Professor, Department of Neurosurgery
Brown University
Director, Molecular Neuroscience & Neuro-oncology Research
Providence, RI, USA

Hangout Title: “Role of an Egr2 long antisense RNA in nerve injury response”
Hangout Schedule: Oct 27th: 9am EST/8 am CST/6 am PST/6.30 pm IST



Publications

Martinez-Moreno M, O'Shea, TM, Zepecki, JP, Olaru, A, Ness, JK, Langer R, Tapinos N. Regulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA.   Cell Reports 2017, DOI: 10.1016/j.celrep.2017.07.068

Ness JK, Skiles AA, Yap E-H, Fiser A, Tapinos N. Nuc-ErbB3 regulates H3K27me3 levels and HMT activity to establish epigenetic repression during peripheral myelination. Glia 2016, DOI: 10.1002/glia.22977

Slotkin JR, Ness JK, Snyder KM, Skiles AA, Woodard EJ, O’Shea T, Layer RT, Aimetti AA, Toms SA, Langer R, Tapinos N. Sustained local release of methylprednisolone from a thiol-acrylate poly(ethylene glycol) hydrogel for treating chronic compressive radicular pain. Spine 2015, PMID: 26630427 [Epub ahead of print]

Pujato M, Kieken F, Skiles A, Tapinos N, Fiser A. Prediction of DNA binding motifs from three dimensional models of transcription factors; identifying tlx3 regulated genes. Nucleic Acids Res 2014, DOI: 10.1093/nar/gku1228

Averick SE, Paredes E, Dey SK, Snyder KM, Tapinos N, Matyjaszewski K, Das SR. Autotransfecting short interfering RNA through facile covalent polymer escorts. J. Am. Chem. Soc 2013, DOI: 10.1021/ja404520j 

Ness JK, Snyder KM, Tapinos N.  Lck tyrosine kinase mediates β1-integrin signaling to regulate Schwann cell cytoskeletal rearrangements, migration and myelination. Nat Commun 2013, 4:1912. Doi:10.1038/ncomms2928

Tadepalli A, Sudol I, Tapinos N. Combinatorial action of miRNAs regulates transcriptional and post-transcriptional gene silencing following in vivo PNS injury. PLoS One 2012, 7;(7): e39674

Hinterseher I, Erdman R, Donoso LA, Vrabec TR, Schworer CM, Lillvis JH, Boddy AM, Derr K, Golden A, Bowen WD, Gatalica Z, Tapinos N, Elmore JR, Franklin DP, Gray JL, Garvin RP, Gerhard GS, Carey DJ, Tromp G, Kuivaniemi H. Role of Complement Cascade in Abdominal Aortic Aneurysms. Arterioscler Thromb Vasc Biol. 2011 Apr 14.

Tadepalli A, Ness JM, Aliste CM, Fiser A, Tapinos N. A nuclear variant of ErbB3 receptor tyrosine kinase regulates Ezrin distribution and Schwann cell myelination.  J. Neurosci.  2011 March 30; 31(13): 5106-5119.

Selected by Faculty of 1000
Tapinos N, Ohnishi M, Rambukkana A. ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli. Nat. Med. 2006 Aug 4; 12(8): 961-966.

Selected by Faculty of 1000
Im JS, Tapinos N, Chae G, Illarionov PA, Besra GS, DeVries G, Modlin RL, Sieling P, Rambukkana A, Porcelli SA.  Expression of CD1d molecules by human Schwann cells and potential interactions with immunoregulatory invariant NK T cells.   J. Immunol. 2006 Oct 15; 177(8): 5226-5235.

Tapinos N, Rambukkana A. Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9188-93.

Rambukkana A, Zanazzi G, Tapinos N, Salzer JL.  Contact-dependent demyelination by Mycobacterium leprae in the absence of immune responses.  Science.  2002 May 3;296(5569):927-31.

Selected by Faculty of 1000
Triantafilopoulou A, Tapinos N*, Moutsopoulos HM.  Evidence for Coxsackievirus infection in primary Sjogren’s syndrome.  Arthritis Rheum.  2004 Sep;50(9):2897-902. (*: equal contribution)

Tapinos N, Polihronis M, Thyphronitis G, Moutsopoulos HM.  Characterization of the CRISP-3 gene as an early transcribed gene with a putative role in the pathophysiology of Sjogren’s syndrome.  Arthritis Rheum. 2002 Jan;46(1):215-22.

Tapinos N, Polihronis M, Tzioufas AG, Moutsopoulos HM.  Sjogren’s syndrome: autoimmune epithelitis.   Adv Exp Med Biol. 1999;455:127-34. 

Xanthou G, Tapinos N, Polihronis M, Nezis IP, Margaritis LH, Moutsopoulos HM.  CD4 cytotoxic and dendritic cells in the immunopathologic lesion of Sjogren’s syndrome.  Clin Exp Immunol. 1999 Oct;118(1):154-63.

Tapinos N, Polihronis M, Moutsopoulos HM.  Lymphoma development in Sjogren’s syndrome: novel p53 mutations.  Arthritis Rheum. 1999 Jul;42(7):1466-72.

Polihronis M, Tapinos N, Tzioufas AG, Moutsopoulos HM.  Sjogren’s syndrome: the significance of epithelial cells.  In: Shoenfeld Y, eds.  The decade of autoimmunity.  Elsevier Sciences 135-141, 1999.

Tapinos N, Polihronis M, Tzioufas AG, Skopouli FN.  Immunopathology of Sjogren’s syndrome (invited review).  Ann Med Interne (Paris). 1998 Feb;149(1):17-24. 

Polihronis M, Tapinos N, Theocharis SE, Economou A, Kittas C, Moutsopoulos HM.  Modes of epithelial cell death and repair in Sjogren’s syndrome.  Clin Exp Immunol. 1998 Dec;114(3):485-90.