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NLRP12-PANoptosome activates PANoptosis and pathology in response t…

Multifaceted nanoparticles: emerging mechanisms and therapies in ne…

Transcriptional drifts associated with environmental changes in end…

How Botox enters the brain cells

Presynaptic targeting of botulinum neurotoxin type A requires a tri…

Sleep is required to consolidate odor memory and remodel olfactory…

The effects of caloric restriction on adipose tissue and metabolic…

Gut microbiome changes linked to precancerous colon polyps

Nuclear lamina erosion-induced resurrection of endogenous retroviru…

Optical opening of the blood-brain barrier for targeted and ultra-s…

Artificial intelligence system predicts consequences of gene modifi…

Deep-brain stimulation during sleep strengthens memory

Augmenting hippocampal-prefrontal neuronal synchrony during sleep e…

Ubiquitin-independent proteasomal degradation driven by C-degron pa…

RNA-guided mechanisms driving cell fate

Apicobasal RNA asymmetries regulate cell fate in the early mouse em…

The enteric nervous system relays psychological stress to intestina…

The shape of the brain influences the way it works

Geometric constraints on human brain function

Ectopic Pregnancy and Lifesaving Care

ER proteostasis regulators cell-non-autonomously control sleep

Protocol to establish a genetically engineered mouse model of IDH1-…

Gene expression signature that predicts progression of type 1 diabetes

Gene expression signature predicts rate of type 1 diabetes progression

The mechanisms behind swallowing

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility

Insulin detection in diabetes mellitus: challenges and new prospects

A new mechanism for sodium salt detoxification in plants

A salt stress-activated GSO1-SOS2-SOS1 module protects the Arabidop…

Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate…

Leishmania parasite manipulates organism's defense system to continue replicating

Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection

How apoE4 and complement factor contribute to neuroinflammation

Computational design of dynamic receptor–peptide signaling complexes

Computational design of dynamic receptor– peptide signaling complexes applied to chemotaxis

Sphingosine-1-phosphate transporter structure revealed!

Potentiation of neuronal activity by tonic GluD1 current in brain slices

Exercise metabolism and adaptation in skeletal muscle

Reversing treatment-resistant depression with targeted neurostimulation

Targeted neurostimulation reverses a spatiotemporal biomarker of treatment-resistant depression

How our cells kill themselves

Structural basis of NINJ1-mediated plasma membrane rupture in cell death

AI predicts the function of enzymes

A general model to predict small molecule substrates of enzymes based on machine and deep learning

Emerging frontiers in regenerative medicine

Designed active-site library reveals thousands of functional GFP variants

Promoting regeneration while blocking cell death preserves motor neuron function in a model of ALS

Massively parallel base editing to map variant effects in human hematopoiesis

CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis

Hippocampo-cortical circuits for selective memory encoding, routing, and replay

A multivariate regressor of patterned dopamine release predicts relapse to cocaine

A tumor protein p63 isoform that induces rheumatoid arthritis and is targeted by methotrexate

TAp63, a methotrexate target in CD4 + T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis

Lipid droplet biogenesis and functions in health and disease

Brain signatures for chronic pain!

Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia

How increase in blood sugar affects Alzheimer's

KATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer's disease-related pathology

The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage

Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models

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