Researchers have found a potential new strategy to treat peritoneal carcinomatosis, a metastatic form of intra-abdominal cancer, where patients are presented with limited treatment options and poor overall survival. Published in Cell Reports Medicine, the findings provide a way to identify more effective treatments for patients with metastatic intra-abdominal cancers by targeting what fuels cancer cells.
A widely accepted scientific hypothesis is that cancer (“seed”) spreads onto the organ surfaces (“soil”) through a series of complex interactions in the body. Most cancer treatments directly target the “seed” such as through the use of chemotherapy, which inhibits cancer cell division. In the last nine years, immunotherapy has become increasingly popular as a means of cancer treatment, altering the “soil” by enlisting the body’s immune system to target cancer cells. In this latest research, findings show it is possible to target “water” to create an arid environment thus making it inhospitable for tumor cell growth.
The team of researchers, excess fluid (“water”) present in the abdomen of patients with metastatic intra-abdominal cancers, can be directly targeted to remove the fuel that drives cancer growth. By interrogating the proteins in ascites, the team found that PAI-1 (plasminogen activator inhibitor 1) is a good marker of response to direct inhibition and could potentially curb cancer cell proliferation. Prior to the team’s discovery, PAI-1 was not known to be related to the growth of intra-abdominal cancers.
Using biological samples from 150 intra-abdominal cancer patients, the team further identified a panel of three biomarkers that could predict patient outcomes as well as responsiveness to PAI-1 therapy. The findings were confirmed with models incorporating the tripartite combination of “seed”, “soil” and “water”.
The research team is currently working with multiple government agencies and pharmaceutical partners to harness the research findings of this study to realize the potential of targeting “water” in cancer patients.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00026-X
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fligand-mediated-pai-1&filter=22
A novel treatment strategy to tackle metastatic intra-abdominal cancer
- 1,074 views
- Added
Latest News
Fertility treatments could…
By newseditor
Posted 05 Jul
Extended-release ketamine t…
By newseditor
Posted 05 Jul
How an unstructured protein…
By newseditor
Posted 04 Jul
Precise control of endogeno…
By newseditor
Posted 04 Jul
Microglial TGF-β1 ligand re…
By newseditor
Posted 04 Jul
Other Top Stories
Macrophages in tumor microenvironment take up more glucose than can…
Read more
Genetic intra-tumor heterogeneity across 2.6K human cancer genomes
Read more
Pregnancy-associated breast cancer linked to inflammation
Read more
DNA supercoiling controls gene expression
Read more
Super-enhancers in triple-negative breast cancer!
Read more
Protocols
A systems biology-based ide…
By newseditor
Posted 05 Jul
Tongue orthotopic xenograft…
By newseditor
Posted 04 Jul
Monitoring norepinephrine r…
By newseditor
Posted 01 Jul
BicemuS: A new tool for neu…
By newseditor
Posted 26 Jun
Deciphering spatial domains…
By newseditor
Posted 23 Jun
Publications
Prevention of Falls in Olde…
By newseditor
Posted 05 Jul
The primitive endoderm supp…
By newseditor
Posted 05 Jul
Migrasome biogenesis: when…
By newseditor
Posted 05 Jul
Extended-release ketamine t…
By newseditor
Posted 05 Jul
Regulation of stress-induce…
By newseditor
Posted 04 Jul
Presentations
Myelin plasticity in the ve…
By newseditor
Posted 10 Jun
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar