Researchers have revealed unprecedented insights into CD4+ T cells, a type of immune cell, which show promise for immunotherapies against melanoma, the most severe form of skin cancer
In the study published in Science Immunology, the researchers found that CD4+ T cells, traditionally called ‘helper T cells’ for their role in aiding the activation of other immune cells, are remarkably effective in controlling melanoma.
The lead author of the study, said this discovery challenges the conventional understanding of the role of CD4+ T cells in cancer immunity.
“Our in-depth study, using animal models, unravelled the complex biology of CD4+ T cells in melanoma and how they control cancer,” explained the author.
“Using microscopic live imaging, we visualised the activities and interactions of CD4+ T cells with other cell types in the tumor microenvironment. Our findings challenge previous assumptions by showing that CD4+ T cells can combat tumors through a multitude of pathways.”
The detailed analysis revealed the genetic makeup, developmental states and functions of CD4+ T cells in melanoma, showing the potential of harnessing CD4+ T cells for future therapies against the skin cancer.
The senior author of the study, said that understanding CD4+ T cell responses could pave the way for more effective immunotherapies against melanoma.
“While CD4+ T cells are often viewed as accessory cells regulating the function of other immune cells, our work shows they can work effectively on their own. Therefore, harnessing their potential therapeutically holds great promise for the development and improvement of current cancer immunotherapies,” said the author.
https://www.science.org/doi/10.1126/sciimmunol.adi9517
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fcd4-t-cell-immunity&filter=22
Role of CD4+ T cells from helpers to melanoma fighters
- 1,040 views
- Added
Latest News
How antisense non-coding RN…
By newseditor
Posted 07 Jul
3D maps of diseased tissues…
By newseditor
Posted 06 Jul
How GLP-1 receptor agonists…
By newseditor
Posted 06 Jul
Pan-cancer proteogenomics e…
By newseditor
Posted 05 Jul
Fertility treatments could…
By newseditor
Posted 05 Jul
Other Top Stories
Afternoon chemotherapy improves treatment outcomes in female lympho…
Read more
A new DNA repair mechanism that hinders cancer treatment
Read more
How tumor suppressor loss enhances breast cancer
Read more
Structural insights reveal how SPOP protein contributes to cancer
Read more
Telomeres, mitochondria, and inflammation work together to prevent…
Read more
Protocols
Pan-cancer proteogenomics c…
By newseditor
Posted 05 Jul
A systems biology-based ide…
By newseditor
Posted 05 Jul
Tongue orthotopic xenograft…
By newseditor
Posted 04 Jul
Monitoring norepinephrine r…
By newseditor
Posted 01 Jul
BicemuS: A new tool for neu…
By newseditor
Posted 26 Jun
Publications
dsRNA formation leads to pr…
By newseditor
Posted 07 Jul
BACH1 inhibits senescence,…
By newseditor
Posted 07 Jul
Bone transport induces the…
By newseditor
Posted 06 Jul
Hypothalamic neuronal activ…
By newseditor
Posted 06 Jul
Prevention of Falls in Olde…
By newseditor
Posted 05 Jul
Presentations
Myelin plasticity in the ve…
By newseditor
Posted 10 Jun
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar