New research has mapped changes in tumor-related bacteria to uncover potential new strategies to combat the rise of young-onset colorectal cancer (CRC) in people under the age of 50.
The research reveals differences in tumor-related bacteria associated with young-onset colorectal cancer. Published in eBioMedicine (part of Lancet Discovery Science), the findings could lead to new screenings or treatments for this population.
According to the American Cancer Society, the incidence and mortality of young-onset colorectal cancer have increased by 1.5% and 1.2% per year, respectively. If this trend continues, a Journal of the National Cancer Institute report estimates the incidence of colon cancer would double and rectal cancer would quadruple in this age group by 2030.
“The unexplained rise of young-onset colorectal cancer is of great concern,” said the primary investigator of the study. “Our team discovered that bacteria were more abundant and compositionally distinct in tumors from young-onset patients. These insights help us to better understand the disease causes and inform new prevention approaches, diagnostic markers, and therapeutic targets.”
This retrospective study, used gene sequencing technology to compare tissue samples from 136 young-onset colorectal cancer patients with 140 average-age patients with the disease. They identified unique tumor-related bacteria in the younger cohort and found that they were more likely to have left-sided, rectal and advanced stage tumors. Key microbes associated with young-onset cancers included Akkermansia and Bacteroides.
“By detailing this microbial signature of young-onset disease, we can look toward new screening biomarkers and drugs targeting related bacteria,” said the author.
The author added that “further research is needed into how lifestyle factors such as diet, medications and obesity may impact gut bacteria and contribute to young-onset colon cancers.”
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00015-X/fulltext
Latest News
Psychosocial experiences ar…
By newseditor
Posted 25 Jun
How a microbe and a prebiot…
By newseditor
Posted 24 Jun
Slowing inflammation may bo…
By newseditor
Posted 24 Jun
Cellular senescence in norm…
By newseditor
Posted 24 Jun
Neuronal communication capt…
By newseditor
Posted 24 Jun
Other Top Stories
Autophagy role in axonal integrity in the brain
Read more
A salvage pathway in mitochondria to repair itself
Read more
A gene that increases risk of Alzheimer's disease discovered
Read more
Artificial intelligence detects emotions in mice
Read more
Junk food orders up trouble for young brains
Read more
Protocols
Deciphering spatial domains…
By newseditor
Posted 23 Jun
High-throughput volumetric…
By newseditor
Posted 21 Jun
Bioengineered human colon o…
By newseditor
Posted 14 Jun
Development of an efficient…
By newseditor
Posted 12 Jun
A co-culture system of macr…
By newseditor
Posted 10 Jun
Publications
Arabidopsis CaLB1 undergoes…
By newseditor
Posted 25 Jun
Cellular senescence in norm…
By newseditor
Posted 24 Jun
Four dimensions of naturali…
By newseditor
Posted 24 Jun
Acetate reprogrammes tumour…
By newseditor
Posted 24 Jun
Retrograde adenosine/A2A re…
By newseditor
Posted 24 Jun
Presentations
Myelin plasticity in the ve…
By newseditor
Posted 10 Jun
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar