While some diseases and disorders can be easily attributed to specific genetic mutations, for many diseases — especially neuropsychiatric ones — the causes are much more complicated, influenced by both genetic and environmental factors. A new study examined data from over 400,000 individuals to better understand how those two factors play into the variations seen in a number of neuropsychiatric disorders, with the hope of eventually identifying ways that individuals who are at risk can modify their environments to protect their mental health. The research was published in Cell Reports Medicine.
“We’ve known for a long time that environmental factors have a great impact on neuropsychiatric diseases, so we wanted to look at how environmental factors interact with genetic ones,” said the first author on the study. “Our lab has access to the data for millions of people and their family relationships, which helps us to model shared genetic factors between family members, as well as shared environmental factors.”
The researchers used a database with health information from over 100,000 U.S. families to model those genetic factors, and linked it together with environmental data from the EPA through the ZIP codes and counties that the individuals and families had lived in.
According to their models, gene-environment interactions account for only a small portion of the variations seen in the rates of some psychiatric disorders, such as depression and substance abuse. Other disorders, however, showed that gene-environment interactions accounted for a much larger proportion, including attention-deficit/hyperactivity disorder (ADHD), anxiety/phobic disorders, recurrent headaches, sleep disorders and post-traumatic stress disorder (PTSD).
These results demonstrate the importance of considering not just an individual’s genetic background, but also their environmental exposure history.
“Genetics is viewed by many people as something like a verdict — you can’t change it,” said the senior author on the study. “Finding these gene-environment interactions give us hope that we can find some genetic variance that interactions with the environment so that, ideally, you could change your environment and escape the disease.”
For example, if a patient were to have a gene that put them at increased risk of migraines when exposed to hot climates, a physician might suggest they ensure that they have air conditioning in their home and avoid the head.
These kinds of studies are typically challenged by a lack of sufficient data, particularly when it comes to environmental data. “Environment is not well defined,” said a staff scientist. “And it’s massive. You could potentially measure billions of different environmental details to determine what’s important.”
The researchers also pointed out that environment can include more than simply the molecules measured by the EPA in the air, water and soil. “In this study, we’re looking specifically at living environments and environmental exposures, but an individual’s personal experience is also a kind of exposure,” said the author. “Especially when you are considering psychiatric diseases. For example, understanding the interactions children have in school would be very important, but it’s very, very difficult to collect this data on a large scale.”
In future research, the team hopes to examine some of these interactions more directly. “In this study, we just modeled a general interaction between genes and environment,” said the author. “Next, we could see if we can identify specific pairs of genes and environmental factors that play a role in the development of disease.”
Long term, and with enough data, the researchers believe they could even develop lifestyle plans based on an individual’s genetic makeup. “If we were able to identify a catalog of genetic variants interacting with specific environmental stimulation, we could design personalized environmental plans for patients at risk,” said the senior author.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00285-3
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fgene-environment&filter=22
Interactions between genetics and the environment = variability in neuropsychiatric disorders
- 1,119 views
- Added
Latest News
A new gene-editing system
By newseditor
Posted 23 May
How ketamine's molecular ac…
By newseditor
Posted 23 May
Therapeutic avenues in bone…
By newseditor
Posted 23 May
Linking key nutrients with…
By newseditor
Posted 23 May
Ferroptosis in fatal COVID-…
By newseditor
Posted 22 May
Other Top Stories
Sensor that makes synapses fast
Read more
Protein that protects against fatty liver identified!
Read more
Protein from injured neurons predicts brain recovery after out-of-h…
Read more
Molecular signal for maintaining adult neuron identified!
Read more
What causes sleepiness when sickness strikes
Read more
Protocols
Efficient expansion and CRI…
By newseditor
Posted 21 May
Massively parallel in vivo…
By newseditor
Posted 20 May
Breast cancer-on-chip for p…
By newseditor
Posted 16 May
Methods for making and obse…
By newseditor
Posted 15 May
Mime-seq 2.0: a method to s…
By newseditor
Posted 13 May
Publications
Patterning and folding of i…
By newseditor
Posted 23 May
Peri-ictal activation of do…
By newseditor
Posted 23 May
Ancestry, ethnicity, and ra…
By newseditor
Posted 23 May
Ketamine can produce oscill…
By newseditor
Posted 23 May
Upregulation of neuronal ER…
By newseditor
Posted 23 May
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar