The quest for rejuvenation treatments often targets senescent cells, despite them having a positive physiological role in health in many recent cases, a leading researcher has warned.
In a paper published in Science the author identifies that senescent cells which have been variously referred to as responsible for ageing actually have various positive health impacts and targeting them therapeutically could be detrimental.
The author highlights the important role that cellular senescence plays in the development of several tissues and organs as well as:
-
inflammation and wound healing,
-
tumour suppression,
-
insulin secretion in pancreatic beta cells,
-
and has structural roles in the vascular system and placenta.
Senescence has also been observed in tissue regeneration in some animals including in mice, where hepatic stellate cells which are crucial to normal liver functioning become senescent following injury.
The author of the paper said: “The role of cellular senescence in ageing and age-related diseases is a major area of research, which has led to the ongoing development of therapies targeting senescent cells.
“Recent findings, however, have revealed a surprising and growing number of normal physiological roles of senescent cells. Strikingly, these results showing that senescent cells play important physiological roles and raise major questions about the rationale, efficacy and safety of targeting senescent cells therapeutically.
While it’s clear that there are some instances in which cellular senescence is implicated in ageing diseases, targeting senescent cells therapeutically entails risks and may not be the way to go in order to tackle ageing.”
https://www.science.org/doi/10.1126/science.adj7050
http://sciencemission.com/site/index.php?page=news&type=view&id=health-science%2Fcellular-senescence-in&filter=22
Latest News
Sex differences in neurolog…
By newseditor
Posted 30 Jun
A neutralizing antibody blo…
By newseditor
Posted 30 Jun
Novel epigenic editor, CHAR…
By newseditor
Posted 30 Jun
Multiomics identifies ALS s…
By newseditor
Posted 28 Jun
Reducing age-related inflam…
By newseditor
Posted 28 Jun
Other Top Stories
Discovery of molecule responsible for birth timing could lead to pr…
Read more
Sox9 is required for a normal epithelial repair process after acute…
Read more
Altering daily light-dark cycles affects fertility in middle-aged f…
Read more
Happiness spreads but depression doesn't
Read more
Anti-aging tricks from dietary supplement seen in mice
Read more
Protocols
BicemuS: A new tool for neu…
By newseditor
Posted 26 Jun
Deciphering spatial domains…
By newseditor
Posted 23 Jun
High-throughput volumetric…
By newseditor
Posted 21 Jun
Bioengineered human colon o…
By newseditor
Posted 14 Jun
Development of an efficient…
By newseditor
Posted 12 Jun
Publications
Loss of GPR75 protects agai…
By newseditor
Posted 30 Jun
Effects of evening smartpho…
By newseditor
Posted 30 Jun
Antibody-activation of conn…
By newseditor
Posted 30 Jun
Mechanism of chaperone coor…
By newseditor
Posted 29 Jun
TMC7 functions as a suppres…
By newseditor
Posted 29 Jun
Presentations
Myelin plasticity in the ve…
By newseditor
Posted 10 Jun
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar