Feeding after fasting could provide an answer to combatting the effects of old age on the blood stem cells that often lead to life-threatening blood cancer, greater susceptibility to infections, and can even contribute to degenerative disorders in the elderly, according to a study in mice led by researchers.
As with all stem cells, the body’s blood-forming stems cells become less effective with age or fail to work at all. Blood-forming stem cells not only create red blood cells, but also all the cells of our immune system, and their decline leads to a whole host of problems for the aging body.
The new study indicates that there is a way to turn back the clock to a younger time and rejuvenate these blood stem cells, restoring their ability to regenerate and fight off age-related diseases.
The researchers found that a cellular recycling process known as autophagy must be activated in old blood stem cells for the cells to survive and function in aged animals.
They identify chronic inflammation in the bone marrow microenvironment as the stressor that drives both metabolic impairment and compensatory autophagy activation in old blood stem cells. They further demonstrate that autophagy is an essential survival response in the context of inflammatory signaling and map out the molecular circuitry involved in the autophagy activation process in this context.
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