High-fat diet (HFD) is known to lead to metabolic dysfunction, which could influence retinal homeostasis and exacerbate retinal degenerative diseases.
To assess how HFD influences retinal degeneration, the researchers. examined the effects of 2–3 weeks of HFD feeding on the retinas of rd10 mice, a model of retinitis pigmentosa (RP).
The authors found that compared with rd10 mice fed a regular chow diet, rd10 mice that experienced a short-term increase in dietary fat intake showed increased photoreceptor degeneration in the retina, reduced retinal responsiveness and photoreceptor cell number, deterioration of photoreceptor morphology and connectivity, and impaired visual acuity.
The HFD feeding aggravated retinal inflammation and oxidative stress and increased expression of inflammatory and oxidative markers in rd10 retinas. HFD feeding also resulted in gut microbiome dysbiosis, altered the diversity of gut bacteria, and increased the abundance of potentially proinflammatory bacteria.
According to the authors, short-term HFD promotes retinal oxidative stress and inflammation as well as gut microbiome dysbiosis and could accelerate retinal degeneration in RP.
https://www.pnas.org/content/118/43/e2100566118
High-fat diet exacerbates retinal degeneration in mouse model
- 1,520 views
- Added
Edited
Latest News
Protein that helps COVID-19…
By newseditor
Posted 26 Jul
Spinal Muscular Atrophy (SM…
By newseditor
Posted 26 Jul
Link between bowel movement…
By newseditor
Posted 26 Jul
Inhibition of IL-11 signall…
By newseditor
Posted 25 Jul
Brain changes linked to obe…
By newseditor
Posted 25 Jul
Other Top Stories
Targeting fat-tissue hormone may lead to type 2 diabetes treatment
Read more
Liver signals to brain to control sugar intake
Read more
Protein Phosphorylation: A Major Switch Mechanism for Metabolic Reg…
Read more
The Genetics of Pediatric Obesity
Read more
The miRNA Interactome in Metabolic Homeostasis
Read more
Protocols
A systems biology approach…
By newseditor
Posted 24 Jul
quantms: a cloud-based pipe…
By newseditor
Posted 22 Jul
Emerging tools and best pra…
By newseditor
Posted 19 Jul
Directly selecting cell-typ…
By newseditor
Posted 17 Jul
PUFFFIN: an ultra-bright, c…
By newseditor
Posted 16 Jul
Publications
Hepatocyte-intrinsic SMN de…
By newseditor
Posted 26 Jul
Aberrant bowel movement fre…
By newseditor
Posted 26 Jul
A pseudoautosomal glycosyla…
By newseditor
Posted 26 Jul
Microglia protect against a…
By newseditor
Posted 26 Jul
Rigor and reproducibility i…
By newseditor
Posted 26 Jul
Presentations
Myelin plasticity in the ve…
By newseditor
Posted 10 Jun
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar