A chromosome is composed of structurally and functionally distinct domains. However, the molecular mechanisms underlying the formation of chromatin structure and the function of subtelomeres, the telomere-adjacent regions, remain obscure.
Researchers report the roles of the conserved centromeric protein Shugoshin 2 (Sgo2) in defining chromatin structure and functions of the subtelomeres in the fission yeast Schizosaccharomyces pombe.
Authors show that Sgo2 localizes at the subtelomeres preferentially during G2 phase and is essential for the formation of a highly condensed subtelomeric chromatin body ‘knob’.
Furthermore, the absence of Sgo2 leads to the derepression of the subtelomeric genes and premature DNA replication at the subtelomeric late origins.
Thus, the subtelomeric specialized chromatin domain organized by Sgo2 represses both transcription and replication to ensure proper gene expression and replication timing.
http://www.nature.com/ncomms/2016/160125/ncomms10393/full/ncomms10393.html
Defining chromatin structure and functions
- 1,195 views
- Added
Edited
Latest News
Hyperactivation of memory c…
By newseditor
Posted 30 May
Maternal obesity may promot…
By newseditor
Posted 30 May
The neuronal basis of opioi…
By newseditor
Posted 30 May
Circadian clock can be leve…
By newseditor
Posted 30 May
Connecting genetic risk for…
By newseditor
Posted 30 May
Other Top Stories
Zika infections unlikely to be passed by kissing, casual contact
Read more
Correcting gene mutation in human embryo!
Read more
A protein in maintaining liver size and function revealed
Read more
How gut microbes fight flu
Read more
Neurons that control brain's body clock identified!
Read more
Protocols
Accessible high-speed image…
By newseditor
Posted 30 May
SEMORE: SEgmentation and MO…
By newseditor
Posted 26 May
Spatially resolved lipidomi…
By newseditor
Posted 24 May
Efficient expansion and CRI…
By newseditor
Posted 21 May
Massively parallel in vivo…
By newseditor
Posted 20 May
Publications
Phase locking of hippocampa…
By newseditor
Posted 30 May
Interactions between physic…
By newseditor
Posted 30 May
Lipid-associated macrophage…
By newseditor
Posted 30 May
Maternal obesity increases…
By newseditor
Posted 30 May
Why cells need iron: a comp…
By newseditor
Posted 30 May
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar