Cancer cells experience an increase in oxidative stress. Excessive accumulation of oxidative stress is harmful to cancer cells. The pentose phosphate pathway (PPP) is a major biochemical pathway that generates antioxidant NADPH. The study demonstrates the important roles of a pentose phosphate pathway (PPP) enzyme, transketolase (TKT), in redox homeostasis in cancer development.
Authors show that TKT is required for cancer growth because of its ability to affect the production of NAPDH to counteract oxidative stress. Authors highlight the clinical relevance of TKT expression in cancers.
They also show that TKT overexpression in cancer cells is a response of Nuclear Factor, Erythroid 2-Like 2 (NRF2) activation, a sensor to cellular oxidative stress. TKT locates at an important position that connects PPP with glycolysis to affect production of antioxidant NADPH.
The preclinical study shows that targeting TKT leads to elevation of oxidative stress, making cancer cells more vulnerable to therapeutic treatment, such as Sorafenib. Using TKT as an example, this study suggests that targeting enzymes for antioxidant production represents a direction for cancer treatment.
http://www.pnas.org/content/early/2016/01/22/1508779113.abstract
Edited
Latest News
AI to analyze clumping prot…
By newseditor
Posted 26 May
Reversible, non-hormonal ma…
By newseditor
Posted 26 May
Dissection of the schizophr…
By newseditor
Posted 26 May
Protease action on controll…
By newseditor
Posted 25 May
Maternal inflammation activ…
By newseditor
Posted 25 May
Other Top Stories
Smartphones may help detect diabetes
Read more
How a genetic variant increase the risk for type 2 diabetes in men
Read more
Leaky gut from excessive fructose consumption
Read more
Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resis…
Read more
How sunlight controls metabolism via brain
Read more
Protocols
SEMORE: SEgmentation and MO…
By newseditor
Posted 26 May
Spatially resolved lipidomi…
By newseditor
Posted 24 May
Efficient expansion and CRI…
By newseditor
Posted 21 May
Massively parallel in vivo…
By newseditor
Posted 20 May
Breast cancer-on-chip for p…
By newseditor
Posted 16 May
Publications
PMI-controlled mannose meta…
By newseditor
Posted 26 May
Protein-membrane interactio…
By newseditor
Posted 26 May
Toward an interventional sc…
By newseditor
Posted 26 May
Cryo-EM reveals that iRhom2…
By newseditor
Posted 25 May
Fetal brain response to mat…
By newseditor
Posted 25 May
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar