People living with or beyond cancer are more likely to die from stroke than the general public, according to a new research published in Nature Communications, and certain types of cancer may boost the risk even more.
Researchers found that compared to the general population, people who have or have had cancer are more than twice as likely to die of a stroke, and the risk increases with time. Additionally, cancers of the breast, prostate or colorectum were the type most commonly associated with fatal stroke.
"Previous research has shown that most cancer patients aren't going to die of their cancer, they're going to die of something else," the senior author said. "A stroke is one possibility. Our findings suggest that patients may benefit from a screening program to help prevent some of these early deaths from stroke, as well as help identify which patients we could target with those preventative efforts."
According to the researchers, cancer is the leading cause of death in the United States, with stroke being the fifth leading cause. But while institutions like the American Heart Association and the National Comprehensive Cancer Network provide separate guidelines for stroke prevention and advice for people beyond cancer treatment, there is little guidance for preventing strokes in people who have or have had cancer.
The researchers used data gathered from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) program. SEER includes data about cancer incidence, survival, treatment and age and year of diagnosis, and covers 28 percent of the U.S. population.
For the current study, the researchers used SEER data on more than 7.2 million patients who had been diagnosed with invasive cancer -- cancer that has spread beyond the tissue in which it originally developed -- between 1992 and 2015.
The researchers found that out of 7,529,481 cancer patients, 80,513 died of a stroke. Males and females had equal chances of dying from a stroke, but those diagnosed with cancer at a younger age had a higher chance of a fatal stroke.
Additionally, they found that among those diagnosed with cancer before they turned 40, most strokes occurred in people treated for brain tumors and lymphomas. In patients diagnosed with cancer above the age of 40, fatal strokes were most commonly associated with cancer of the prostate, breast and colorectum.
The senior author said one explanation for the increased risk could be that many people who are diagnosed with cancer are in a "prothrombotic" state, which means they are more likely to form a blood clot.
"That blood clot may then go to the lungs and cause a pulmonary embolism, for example, or cause a stroke if it goes to the brain," the senior author said. "In general, it's an underlying theme and risk factor for a lot of cancer patients. And because certain cancers like those of the prostate, breast and colorectum are some of the most common cancers, that could also help explain that high association."
Another author said alternate explanation may stem from the effects of certain types of cancer treatment.
"We can speculate that a subset of cancer patients are receiving chemotherapy or radiation treatments that may have a direct effect on the blood vessels to the brain and could increase stroke risk," the author said. "This may be particularly true in patients with brain cancer."
The researchers added that future studies could help pinpoint mechanisms and further establish the relationship between cancer and strokes.
https://www.nature.com/articles/s41467-019-13120-6
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fstroke-among-cancer&filter=22
Cancer patients have more risk of dying from stroke
- 4,087 views
- Added
Edited
Latest News
Circadian rhythms can influ…
By newseditor
Posted 27 Apr
With hybrid brains, these m…
By newseditor
Posted 27 Apr
Blocking activation of NF-κ…
By newseditor
Posted 27 Apr
Vitamin D regulates microbi…
By newseditor
Posted 27 Apr
Role of alternative splicin…
By newseditor
Posted 27 Apr
Other Top Stories
Both nature and nurture contribute to signatures of socioeconomic s…
Read more
Improved cognition and mood by inducing neurogenesis via optogeneti…
Read more
STING mediates neurodegeneration and neuroinflammation in Parkinson…
Read more
CRISPR-based strategy to edit multiple genes
Read more
New proteins in DNA repair!
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Single dose creatine improv…
By newseditor
Posted 27 Apr
Autonomous circadian rhythm…
By newseditor
Posted 27 Apr
Functional sensory circuits…
By newseditor
Posted 27 Apr
Positive selection CRISPR s…
By newseditor
Posted 27 Apr
Focal clusters of peri-syna…
By newseditor
Posted 27 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar