The same bacteria present in primary tumors of patients with colorectal cancer are also present in liver metastases, a new study finds. What's more, presence of the bacteria was found to correlate with tumor growth.
Previous studies have found an abundance of Fusobacterium nucleatum in human colon cancers. To explore whether colon cancer that has spread to other parts of the body also harbors the bacteria, researchers analyzed samples of primary tumors and corresponding liver metastases in colon cancer patients.
They not only confirmed the presence of Fusobacterium in the metastases, but found that the strains were highly similar to those found in primary tumors of the same individual. Notably, patients who did not have Fusobacterium within their primary tumors also lacked the bacteria in their metastases.
When the researchers transplanted Fusobacterium-positive tumors into mice, the tumors took hold, whereas tumors lacking the bacteria did not. Lastly, antibiotic treatment of mice with Fusobacterium-positive tumors reduced the amount of Fusobacteriumin the tumors and slowed tumor growth.
Based on these results, the authors speculate that Fusobacterium travels with metastatic tumor cells to distant organs, perhaps aiding their colonization at these site.
http://www.vhio.net/en/bacterium-in-colorectal-cancer-bystander-passenger-or-driver-of-metastatic-spread/#iLightbox[gallery10475]/0
http://science.sciencemag.org/content/early/2017/11/20/science.aal5240
Latest News
Circadian rhythms can influ…
By newseditor
Posted 27 Apr
With hybrid brains, these m…
By newseditor
Posted 27 Apr
Blocking activation of NF-κ…
By newseditor
Posted 27 Apr
Vitamin D regulates microbi…
By newseditor
Posted 27 Apr
Role of alternative splicin…
By newseditor
Posted 27 Apr
Other Top Stories
Short, intense exercise bursts can reduce heart risk to teens
Read more
Four gut bacteria decrease asthma risk in infants
Read more
Childhood malnutrition and gut viruses
Read more
Caffeine at night delays human circadian clock
Read more
Birth control pills pose small but significant stroke risk
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Single dose creatine improv…
By newseditor
Posted 27 Apr
Autonomous circadian rhythm…
By newseditor
Posted 27 Apr
Functional sensory circuits…
By newseditor
Posted 27 Apr
Positive selection CRISPR s…
By newseditor
Posted 27 Apr
Focal clusters of peri-syna…
By newseditor
Posted 27 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar