Intelligence is associated with important economic and health-related life outcomes. Despite high heritability estimates of 45% in childhood and 80% in adulthood, only a handful of genes had previously been associated with intelligence and for most of these genes the findings were not reliable. The study, published in the journal Nature Genetics, uncovered 52 genes for intelligence, of which 40 were completely new discoveries. Most of these genes are predominantly expressed in brain tissue.
The genes we detect are involved in the regulation of cell development, and are specifically important in synapse formation, axon guidance and neuronal differentiation. These findings for the first time provide clear clues towards the underlying biological mechanisms of intelligence”, says Principal Investigator of the study.
The study also showed that the genetic influences on intelligence are highly correlated with genetic influences on educational attainment, and also, albeit less strongly, with smoking cessation, intracranial volume, head circumference in infancy, autism spectrum disorder and height. Inverse genetic correlations were reported with Alzheimer’s disease, depressive symptoms, smoking history, schizophrenia, waist-to-hip ratio, body mass index, and waist circumference.
“These genetic correlations shed light on common biological pathways for intelligence and other traits. Seven genes for intelligence are also associated with schizophrenia; nine genes also with body mass index, and four genes were also associated with obesity. These three traits show a negative correlation with intelligence”, says first author of the study. “So, a variant of gene with a positive effect on intelligence, has a negative effect on schizophrenia, body mass index or obesity.”
Future studies will need to clarify the exact role of these genes in intelligence in order to obtain a more complete picture of how genetic differences lead to differences in intelligence. “The current genetic results explain up to 5% of the total variance in intelligence. Although this is quite a large amount of variance for a trait as intelligence, there is still a long road to go: given the high heritability of intelligence, many more genetic effects are expected to be important, and these can only be detected in even larger samples”, says the senior author.
https://www.vu.nl/en/news-agenda/news/2017/apr-jun/scientists-find-new-genetic-roots-for-intelligence.aspx
https://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3869.html
Latest News
Protein that helps COVID-19…
By newseditor
Posted 26 Jul
Spinal Muscular Atrophy (SM…
By newseditor
Posted 26 Jul
Link between bowel movement…
By newseditor
Posted 26 Jul
Inhibition of IL-11 signall…
By newseditor
Posted 25 Jul
Brain changes linked to obe…
By newseditor
Posted 25 Jul
Other Top Stories
Activated dopamine receptor structure solved!
Read more
Artificial synapse that works with living cells
Read more
Are there concept cells in the brain?
Read more
A method to map the brain cell change
Read more
Room temperature x-ray crystallography of COVID-19 main protease
Read more
Protocols
A systems biology approach…
By newseditor
Posted 24 Jul
quantms: a cloud-based pipe…
By newseditor
Posted 22 Jul
Emerging tools and best pra…
By newseditor
Posted 19 Jul
Directly selecting cell-typ…
By newseditor
Posted 17 Jul
PUFFFIN: an ultra-bright, c…
By newseditor
Posted 16 Jul
Publications
Hepatocyte-intrinsic SMN de…
By newseditor
Posted 26 Jul
Aberrant bowel movement fre…
By newseditor
Posted 26 Jul
A pseudoautosomal glycosyla…
By newseditor
Posted 26 Jul
Microglia protect against a…
By newseditor
Posted 26 Jul
Rigor and reproducibility i…
By newseditor
Posted 26 Jul
Presentations
Myelin plasticity in the ve…
By newseditor
Posted 10 Jun
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar