A team of scientists discovered how newly identified neural circuits in the brain's hippocampal formation play a critical role in object-location learning and memory. The study was published in Nature Neuroscience.
Loss of object location memory is one of the key impairments in Alzheimer's disease (AD), the most common form of dementia in the elderly. These new findings in hippocampal circuit mechanisms provide an intriguing new target to counteract AD-related memory impairments.
Authors how that the afferent circuitry of CA1-projecting subicular neurons is biased by inputs from CA1 inhibitory neurons and the visual cortex, but lacks input from the entorhinal cortex. Efferents of the CA1-projecting subiculum neurons also target the perirhinal cortex, an area strongly implicated in object–place learning.
They identify a critical role for CA1-projecting subicular neurons in object-location learning and memory, and show that this projection modulates place-specific activity of CA1 neurons and their responses to displaced objects. Together, the experiments reveal a novel pathway by which cortical inputs, particularly those from the visual cortex, reach the hippocampal output region CA1.
"Our study was made possible by new viral genetic based mapping approaches for examining connectivity between structures. These new mapping tools enabled us to identify novel circuits within and between the hippocampus and cortex," said the senior author.
The researchers used monosynaptic rabies retrograde tracing and herpes (H129)-based anterograde tracing to establish new cortico-hippocampal circuitry associated with subiculum (SUB) projections to hippocampal CA1.
The team revealed the hippocampal sub-circuit mechanism highly relevant to learning and memory disorders including Alzheimer's disease. These findings may be used to better treat Alzheimer's disease and other neurological disorders, delay their onset, and possibly prevent them from developing in the first place.
https://www.nature.com/articles/s41593-019-0496-y
Latest News
Protein that helps COVID-19…
By newseditor
Posted 26 Jul
Spinal Muscular Atrophy (SM…
By newseditor
Posted 26 Jul
Link between bowel movement…
By newseditor
Posted 26 Jul
Inhibition of IL-11 signall…
By newseditor
Posted 25 Jul
Brain changes linked to obe…
By newseditor
Posted 25 Jul
Other Top Stories
Brain receptor controls obesity and energy metabolism
Read more
Circadian clock and body homeostasis
Read more
What is the function of Parkinson's protein in a cell?
Read more
Sounds influence the developing brain earlier than previously thought
Read more
Smartphone app to change your personality
Read more
Protocols
A systems biology approach…
By newseditor
Posted 24 Jul
quantms: a cloud-based pipe…
By newseditor
Posted 22 Jul
Emerging tools and best pra…
By newseditor
Posted 19 Jul
Directly selecting cell-typ…
By newseditor
Posted 17 Jul
PUFFFIN: an ultra-bright, c…
By newseditor
Posted 16 Jul
Publications
Itching Frequency and Neuro…
By newseditor
Posted 27 Jul
Hepatocyte-intrinsic SMN de…
By newseditor
Posted 26 Jul
Aberrant bowel movement fre…
By newseditor
Posted 26 Jul
A pseudoautosomal glycosyla…
By newseditor
Posted 26 Jul
Microglia protect against a…
By newseditor
Posted 26 Jul
Presentations
Myelin plasticity in the ve…
By newseditor
Posted 10 Jun
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar