Scientists have shed light on why some people crave salty food, even when they know it can seriously damage their health.
The study helps researchers understand how the brain controls our appetite for salt, and how it impacts on blood pressure levels.
The findings suggest it could soon be possible to offer heart disease patients a medicine that helps them manage their salt intake and curb the adverse effects of high blood pressure.
Scientists modified mice to remove a gene (11β-hydroxysteroid dehydrogenase type 2 (11βHSD2)) in a small number of cells in the mouse brain. This gene is known to be linked with high blood pressure in humans but the way this is controlled is unclear.
Removing the gene caused the mice to develop a strong appetite for salt - when offered a choice of normal drinking water or saltwater, they consumed three times more saltwater than unmodified mice.
The trial also showed that the modified mice went on to experience high blood pressure for as long as they drank saltwater. When the saltwater was removed their blood pressure returned to normal.
Dexamethasone suppressed endogenous glucocorticoid and abolished the salt-induced blood pressure differential between genotypes. Salt-sensitivity in Hsd11b2.BKO mice was not caused by impaired renal sodium excretion or volume expansion; pressor responses to phenylephrine were enhanced and baroreflexes impaired in these animals.
The findings suggest that the 11βHSD2 gene plays an important role in controlling both the appetite for salt, and its effect in raising blood pressure, scientists say.
The team will now research whether an affordable drug - already used to treat heart disease in some countries - can help to bring salt intake under control in patients with heart failure.
The results have been published in the journal Circulation.
http://circ.ahajournals.org/content/early/2016/03/07/CIRCULATIONAHA.115.019341
Why some people crave salty food
- 1,496 views
- Added
Edited
Latest News
Hyperactive platelets from…
By newseditor
Posted 19 May
Chromatin and RNA interacti…
By newseditor
Posted 18 May
Why patients with ARID1A mu…
By newseditor
Posted 18 May
Smuggling small molecule mo…
By newseditor
Posted 18 May
Men with gene mutations are…
By newseditor
Posted 17 May
Other Top Stories
Neurogenesis from gut microbe secreted molecule
Read more
Monoclonal antibodies that may neutralize many norovirus variants
Read more
A case for intranasal COVID-19 vaccinations
Read more
Why do some people get severe COVID-19?
Read more
How malaria parasite suppresses the immune response
Read more
Protocols
Breast cancer-on-chip for p…
By newseditor
Posted 16 May
Methods for making and obse…
By newseditor
Posted 15 May
Mime-seq 2.0: a method to s…
By newseditor
Posted 13 May
Improved detection of DNA r…
By newseditor
Posted 09 May
Single-cell adhesive profil…
By newseditor
Posted 07 May
Publications
An age-progressive platelet…
By newseditor
Posted 19 May
Immunotherapy for colorecta…
By newseditor
Posted 18 May
Single-cell multiplex chrom…
By newseditor
Posted 18 May
Autophagy preferentially de…
By newseditor
Posted 18 May
Poison Ivy, Poison Oak, and…
By newseditor
Posted 18 May
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar