A study expands the understanding of the molecular pathways that control T cell function and survival and how it relates to declining T cell immunity in the elderly.
The findings outline that the increased metabolism of T cells observed with advanced age was an indication that they were working harder merely to survive.
The study published in Nature Communications contradicts previous knowledge, which suggested an increased metabolism was indicative of T cell function, and will have implications for the development of targeted interventions such as vaccines or immunotherapies to treat age-related immune dysfunction.
T cells play an important role in the body's immune response to viral infections and tumors, but T cell immunity wanes as we age, thus increasing our susceptibility to these diseases.
The authors investigated virtual memory T (TVM) cell metabolism and its association with longevity and functionality. Elevated spare respiratory capacity (SRC) is a feature of TVM, but not antigen-experienced memory T (TMEM), cells and it increases with age in both subsets. The elevated SRC observed in aged mouse TVM cells and human CD8+ T cells from older individuals is associated with a heightened sensitivity to IL-15.
"We've shown that an amped-up metabolism, rather than arming cells to fight pathogens better, is associated with T cell survival over a lifespan. The cells need to substantially increase their metabolism just to survive in the relatively hostile environment of the elderly," the senior author said.
"This work is important because one of the hallmarks of immune aging is the loss of T cells. So it provides clues on how we might promote T cell survival in the elderly, and so boost T cell immunity," the senior author said.
https://www.nature.com/articles/s41467-020-16633-7
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fmetabolic-characteristic&filter=22
Declining T cell immunity in the elderly
- 793 views
- Added
Edited
Latest News
Protein that helps COVID-19…
By newseditor
Posted 26 Jul
Spinal Muscular Atrophy (SM…
By newseditor
Posted 26 Jul
Link between bowel movement…
By newseditor
Posted 26 Jul
Inhibition of IL-11 signall…
By newseditor
Posted 25 Jul
Brain changes linked to obe…
By newseditor
Posted 25 Jul
Other Top Stories
Deep-sleep brain waves predict blood sugar control
Read more
Extracellular cytochrome nanowires appear to be ubiquitous in microbes
Read more
Distinct connectivity patterns for depression associated with traum…
Read more
Antisense therapy restores fragile X protein production in human cells
Read more
Biomarker for allergic reaction in kidneys identified!
Read more
Protocols
A systems biology approach…
By newseditor
Posted 24 Jul
quantms: a cloud-based pipe…
By newseditor
Posted 22 Jul
Emerging tools and best pra…
By newseditor
Posted 19 Jul
Directly selecting cell-typ…
By newseditor
Posted 17 Jul
PUFFFIN: an ultra-bright, c…
By newseditor
Posted 16 Jul
Publications
Hepatocyte-intrinsic SMN de…
By newseditor
Posted 26 Jul
Aberrant bowel movement fre…
By newseditor
Posted 26 Jul
A pseudoautosomal glycosyla…
By newseditor
Posted 26 Jul
Microglia protect against a…
By newseditor
Posted 26 Jul
Rigor and reproducibility i…
By newseditor
Posted 26 Jul
Presentations
Myelin plasticity in the ve…
By newseditor
Posted 10 Jun
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar