A new test revealed that FDA-approved antibiotics — available at your neighborhood pharmacy — can effectively treat superbugs. They are not prescribed, however, because the gold-standard test predicts they will not work. The new test may improve the way antibiotics are developed, tested and prescribed — and it is openly available to all.

The research has significant implications in the fight against bacterial resistance by optimizing the prescription and use of currently available antibiotics and enhancing the efforts to discover new ones.

Developed by a research team, the antibiotic study was published in the journal Cell Reports Medicine. The research addressed a fundamental flaw in the healthcare paradigm for determining antibiotic resistance.  It does not account for environmental conditions in the body that impact drug potency.

By simulating conditions in the body, the new test identified several effective antibiotics rejected by standard testing. Further, when the new and standard tests agreed — a nearly perfect prediction of treatment success or failure was observed.

The study required a tour de force screening of more than 500 antibiotic-bacteria combinations. The findings suggest that the standard test is incorrect ~15% of the time.  And since physicians rely on this test for treatment decisions — it may lead to prescription of the wrong antibiotic.

“People are not Petri plates — that is why antibiotics fail,” said the author.  “Testing under conditions that mimic the body improves the accuracy by which lab tests predict drug potency.”

Physicians are aware of the flaws in the gold-standard test.  When recommended antibiotics do not work, they must rely on their experience to decide on the appropriate antibiotic(s) for their patients. 

This study provides a potential solution to address the disparity between antibiotics indicated by standard testing and actual patient outcomes.  

“Reevaluation of FDA-approved antibiotics may be of far greater benefit than the time and cost of developing new drugs to combat antimicrobial resistance,” explained the author, “potentially leading to significant life-savings and cost-savings.”

“Sepsis treatments are expensive and require long hospital stays,” explained the author, “and testing and re-testing is not only time- and labor-intensive, but also leads to antibiotic resistance.”

The new test will lead to reduced costs for the healthcare industry in their efforts to identify new drugs to fight antimicrobial resistant infections.

“More accurate testing reduces the costs of drug discovery by streamlining detection of lead candidates long before expensive human clinical trials,” said a clinical veterinarian.

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00133-7

http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fre-evaluation-of-fda&filter=22