To efficiently infect human cells, SARS-CoV-2, the virus that causes COVID-19, is able to use a receptor called Neuropilin-1, which is very abundant in many human tissues including the respiratory tract, blood vessels and neurons.
"That SARS-CoV-2 uses the receptor ACE2 to infect our cells was known, but viruses often use multiple factors to maximize their infectious potential" says the head of the research group.
Unlike other respiratory viruses, SARS-CoV-2 infects also the upper respiratory system including the nasal mucosa and consequently spreads rapidly. "This virus is able to leave our body even when we simply breath or talk", the author adds. "The starting point of our study was the question why SARS-CoV, a coronavirus that led to a much smaller outbreak in 2003, and SARS-CoV-2, spread in such a different way even if they use the same main receptor ACE2", explains one of the main contributors of the study.
To understand how these differences can be explained, the researchers took a look at the viral surface proteins, the spikes, that like hooks, anchor the virus to the cells. The author reveals that "when the sequence of the SARS-CoV-2 genome became available, at the end of January, something surprised us. Compared to its older relative, the new coronavirus had acquired an 'extra piece' on its surface proteins, which is also found in the spikes of many devastating human viruses, including Ebola, HIV, and highly pathogenic strains of avian influenza, among others. We thought this could lead us to the answer". The mystery was solved: the extra key binds to neuropilin-1.
Together, the coordinated team of international researchers looked at whether neuropilins were important for infection by SARS-CoV-2. Their experiments now support this hypothesis. Interestingly, an independent team of scientists has obtained similar results and confirmed that the virus spike binds directly to neuropilin-1. The two studies complement each other.
By specifically blocking neuropilin-1 with antibodies, the researchers were able to significantly reduce infection in laboratory cell cultures. "If you think of ACE2 as a door lock to enter the cell, then neuropilin-1 could be a factor that directs the virus to the door. ACE2 is expressed at very low levels in most cells. Thus, it is not easy for the virus to find doors to enter. Other factors such as neuropilin-1 might help the virus finding its door", says the author.
The author cautiously concludes "it is currently too early to speculate whether blocking directly neuropilin could be a viable therapeutic approach, as this could lead to side effects. This will have to be looked at in future studies. Currently our laboratory is testing the effect of new molecules that we have specifically designed to interrupt the connection between the virus and neuropilin. Preliminary results are very promising and we hope to obtain validations in vivo in the near future."
https://www.helsinki.fi/en/news/health-news/open-sesame-researchers-discovered-the-second-key-used-by-the-sars-cov-2-virus-to-enter-into-human-cells
https://science.sciencemag.org/content/early/2020/10/19/science.abd2985
https://science.sciencemag.org/content/early/2020/10/19/science.abd3072.full
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fneuropilin-1-is-a-host&filter=22
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fneuropilin-1&filter=22
The second 'key' used by the SARS-CoV-2 virus to enter into humans discovered!
- 1,043 views
- Added
Edited
Latest News
Father's gut microbes affec…
By newseditor
Posted 08 May
A new brain circuit in mice…
By newseditor
Posted 08 May
Mechanism of choline entry…
By newseditor
Posted 07 May
Link between UTI and breast…
By newseditor
Posted 07 May
Sleep resets brain connections
By newseditor
Posted 07 May
Other Top Stories
Role of alternative autophagy in neurodegeneration
Read more
Which particulate air pollution poses the greatest health risk?
Read more
Genetic link to pre-sympamatic axonal swelling in Alzheimer's disease
Read more
Chewing habits determine early deterioration of dental implants
Read more
Protein accumulation in a genetic heart disease similar to neurode…
Read more
Protocols
Single-cell adhesive profil…
By newseditor
Posted 07 May
Parasympathetic neurons der…
By newseditor
Posted 07 May
Non-invasive measurements o…
By newseditor
Posted 05 May
A validation strategy to as…
By newseditor
Posted 04 May
Generation of rat forebrain…
By newseditor
Posted 03 May
Publications
Paternal microbiome perturb…
By newseditor
Posted 08 May
Truncating NFKB1 variants c…
By newseditor
Posted 08 May
Synaptotagmin-11 facilitate…
By newseditor
Posted 08 May
Astrocytic Slc4a4 regulates…
By newseditor
Posted 08 May
Diabetic retinopathy is a c…
By newseditor
Posted 08 May
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar