Contact between axons and Schwann cells triggers signals required for radial sorting and myelination. Failure in this interaction causes dysmyelination and axonal degeneration.
Despite its importance, few molecules at the axo-glial surface are known.
To identify novel molecules in axo-glial interactions, authors modified the ‘pseudopodia’ sub-fractionation system and isolated the projections that glia extend when they receive juxtacrine signals from axons.
By proteomics they identified the signalling networks present at the glial-leading edge, and novel proteins, including members of the Prohibitin family.
Glial-specific deletion of Prohibitin-2 in mice impairs axo-glial interactions and myelination.
http://www.nature.com/ncomms/2015/150918/ncomms9303/full/ncomms9303.html
Prohibitin-2 is a novel molecule involved in myelination
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