Artificial intelligence (AI) has created new possibilities for designing tailor-made proteins to solve everything from medical to ecological problems. A research team has now successfully applied a computer-based natural language processing model to protein research. Completely independently, the ProtGPT2 model designs new proteins that are capable of stable folding and could take over defined functions in larger molecular contexts. The model and its potential are detailed scientifically in Nature Communications.
Natural languages and proteins are actually similar in structure. Amino acids arrange themselves in a multitude of combinations to form structures that have specific functions in the living organism – similar to the way words form sentences in different combinations that express certain facts.
In recent years, numerous approaches have therefore been developed to use principles and processes that control the computer-assisted processing of natural language in protein research.
"Natural language processing has made extraordinary progress thanks to new AI technologies. Today, models of language processing enable machines not only to understand meaningful sentences but also to generate them themselves. Such a model was the starting point of our research. With detailed information concerning about 50 million sequences of natural proteins, my colleague Noelia Ferruz trained the model and enabled it to generate protein sequences on its own. It now understands the language of proteins and can use it creatively. We have found that these creative designs follow the basic principles of natural proteins," says the senior author.
The language processing model transferred to protein evolution is called "ProtGPT2". It can now be used to design proteins that adopt stable structures through folding and are permanently functional in this state. In addition, the biochemists have found out, through complex investigations, that the model can even create proteins that do not occur in nature and have possibly never existed in the history of evolution. These findings shed light on the immeasurable world of possible proteins and open a door to designing them in novel and unexplored ways.
There is a further advantage: Most proteins that have been designed de novo so far have idealized structures. Before such structures can have a potential application, they usually must pass through an elaborate functionalization process – for example by inserting extensions and cavities – so that they can interact with their environment and take on precisely defined functions in larger system contexts. ProtGPT2, on the other hand, generates proteins that have such differentiated structures innately, and are thus already operational in their respective environments.
"Our new model is another impressive demonstration of the systemic affinity of protein design and natural language processing. Artificial intelligence opens up highly interesting and promising possibilities to use methods of language processing for the production of customized proteins. At the University of Bayreuth, we hope to contribute in this way to developing innovative solutions for biomedical, pharmaceutical, and ecological problems," says the senior author.
Artificial intelligence enables the design of novel proteins
- 960 views
Other Top Stories
Cancer cells spread to other sites in the body through promoting the growth of new 'roads' to travel on. In a study to be published in the top scientific journal, Nature, an international and multidisciplinary team of researchers, discovered how a shift to increased fat utilization is required for the development and growth of these 'roads', termed lymphatic vessels - a special kind of blood vessels…
Critical error – bailing out
Details here are intended only for the website/system-administrator, not for regular website users.
» If you are a regular website user, please let the website staff deal with this problem.
Depending on the error, and only if the website installation finished, you may need to edit the installation options (the info.php file).
ocProducts maintains full documentation for all procedures and tools. These may be found on the ocPortal website. If you are unable to easily solve this problem, we may be contacted from our website and can help resolve it for you.
ocPortal is a CMS for building websites, developed by ocProducts.