Aging-associated epigenetic dysregulation in neurodegeneration

Age-associated epigenetic noise constitutes a shared feature across major neurodegenerative diseases, shaping neuronal vulnerability prior to overt protein aggregation or neuronal loss. 

Rather than reflecting disease-specific chromatin lesions, epigenetic impairments in neurodegeneration appear to emerge from the biased deployment of common epigenetic noise across distinct cell-type-specific regulatory architectures and neural circuit demands.

Epigenetic noise preferentially destabilizes gene networks supporting neuronal identity, synaptic plasticity, metabolic homeostasis, and long-range transcriptional coordination, thereby reducing the resilience of aging brain systems.

Therapeutic strategies aimed at rebalancing, rather than eliminating, epigenetic noise may modify aging trajectories and influence susceptibility to neurodegenerative diseases when aligned with cellular context and disease stage.

https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(26)00077-9

https://sciencemission.com/Epigenetic-noise-in-the-aging-brain