Autism-associated CHD8 controls reactive gliosis and neuroinflammation
During neuroinflammation, glial cells in the brain become reactive but the mechansims that control reactive gliosis is not well understood.
The researchers revealed the role of autism-associated CHD8 in reactive gliosis and neuroinflammation through regulating chromatin landscape and gene transcription in astrocytes.
Chd8 deletion in astrocytes, but not microglia, suppresses reactive gliosis by impeding astrocyte proliferation and morphological elaboration. Astrocyte Chd8 ablation alleviates lipopolysaccharide-induced neuroinflammation and septic-associated hypothermia in mice.
The authors also show that reactive gliosis can be directly mitigated in vivo using an adeno-associated virus (AAV)-mediated Chd8 gene editing strategy.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00987-2
