Broadly neutralizing antibodies against emerging delta-coronaviruses
Porcine delta-coronavirus (PDCoV) recently spilled over to humans, and no countermeasures are approved.
The researchers describe human mAbs that broadly neutralize PDCoV variants by inhibiting host receptor engagement to the RBD.
They perform deep-mutational scanning to enhance our understanding of DCoV immunity and identify a two-mAb cocktail that could potentially limit viral resistance.
https://www.cell.com/immunity/fulltext/S1074-7613(24)00481-3
