Can we ‘recharge’ our cells?
The researchers use nanotechnology to recharge the "powerhouse of the cell" in fight against disease and aging.
When we need to recharge, we might take a vacation or relax at the spa. But what if we could recharge at the cellular level, fighting against aging and disease with the microscopic building blocks that make up the human body?
The ability to recharge cells diminishes as humans age or face diseases. Mitochondria, often called the powerhouse of the cell, are central to energy production. When mitochondrial function declines, it leads to fatigue, tissue degeneration, and accelerated aging. Activities that once required minimal recovery now take far longer, highlighting the role that these organelles play in maintaining vitality and overall health.
While current treatments for ailments related to aging and diseases like type 2 diabetes, Alzheimer’s, and Parkinson’s focus on managing symptoms, the researchers have taken a new approach to fight the battle at the source: recharging mitochondrial power through nanotechnology.
The team has developed molybdenum disulfide (MoS₂) nanoflowers. Named because of their flower-like structure, these nanoparticles contain atomic vacancies that can stimulate mitochondrial regeneration, helping cells generate more energy.
The team published their findings in Nature Communications.
“These findings offer a future where recharging our cells becomes possible, extending healthy lifespans, and improving outcomes for patients with age-related diseases,” said the author.
According to the author, the nanoflowers could offer new treatments for diseases like muscle dystrophy, diabetes, and neurodegenerative disorders by increasing ATP production, mitochondrial DNA, and cellular respiration. They discovered that the atomic vacancies in the nanoflowers stimulate the molecular pathways involved in mitochondrial cell replication.
The authors also provided insights into the mechanisms that could drive the improvement of mitochondrial function.
“This discovery is unique,” the author said. “We are not just improving mitochondrial function; we are rethinking cellular energy entirely. The potential for regenerative medicine is incredibly exciting.”
“By leveraging advanced computational tools, we can decode the hidden patterns in cellular responses to these nanomaterials, unlocking new possibilities for precision medicine,” another author said. “It’s like giving cells the right instructions at the molecular level to help them restore their own powerhouses — mitochondria.”
The next steps for the research team include identifying a method for delivering the nanoflowers to human tissue, with the goal of eventual clinical application.
“In science, it’s often the smallest details that lead to the most profound discoveries,” the author said. “By focusing on the unseen — like atomic vacancies in nanomaterials — we are uncovering new ways to solve big problems. Sometimes, the real breakthroughs come from digging deeper and looking beyond the obvious.”
https://www.nature.com/articles/s41467-024-52276-8
