Circular RNA in cancer
Circular RNAs, also known as circRNAs, are a stable form of RNA found in eukaryotic cells and synthesized via back-splicing.
Certain endogenous circRNAs have the potential to encode proteins and hence the potential for gene expression.
CircRNA may also play a significant roles in various human diseases such as respiratory, endocrine, metabolic, musculoskeletal, cardiovascular, and renal disorders. CircRNA also play a crucial for cancer initiation, progression, and resistance to treatment.
In this Review, the authors highlight examples of functional circRNAs in specifc cancers and their physical co-association with the target and circRNA abundance at stoichiometrically valid quantities. They also discus how circRNAs may work as biomarkers and targeted anticancer agents.
