Effect of microglia depletion in APOE4 Alzheimer’s disease model
The researchers examine the effects of APOE4 and microglial depletion on Alzheimer’s disease (AD) pathogenesis in a chimeric mouse model with transplanted human induced pluripotent stem cell-derived neurons.
They demonstrate the importance of neuronal APOE and the role of both APOE4 and microglia in promoting AD pathologies.
The authors show that neuronal APOE4 promotes Aβ and p-tau pathologies inflammatory response of microglia in the chimeric mouse model.
Microglial depletion reduces neuronal APOE4-induced Aβ and p-tau pathologies.
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00367-9
