How dietary trans-fat induces atherosclerosis
Although it is well known that dietary trans-unsaturated fatty acids (TFAs) induce atherosclerosis, molecular trafficking of TFAs responsible for this association is not well understood.
The researchers demonstrate that TFAs are selectively incorporated by serine palmitoyltransferase (SPT) to synthesize and secrete sphingolipids from cells.
TFA-enriched high-fat diets accelerated hepatic sphingolipid and VLDL secretion to promote atherosclerosis in Ldlr/ mice.
SPT inhibition mitigated trans-fat-driven atherogenesis while diminishing flux of sphingolipids into atherogenic VLDL.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00412-1
