How probiotics inhibits hepatitis B virus
Commensal microbes are promising in the functional cure of HBV infection.
The researchers demonstrate that probiotics and their metabolite spermidine effectively promote the decline of hepatitis B surface antigen (HBsAg0 and inhibit HBV replication
The authors show that probiotics-derived spermidine accumulates in the gut and transports to the liver, where it exhibits a similar anti-HBV effect. Mechanistically, spermidine enhances IFN-γ+CD4+ T cell immunity by autophagy.
Administration of probiotics in HBV patients reveals a preliminary trend to accelerate the decline of serum HBsAg, highlighting the therapeutic potential of probiotics and spermidine for the functional cure of HBV patients.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00593-7
