Hypoparathyroidism with multiple complications
Despite treatment with calcium and active vitamin D, many patients with chronic hypoparathyroidism experience a wide spectrum of symptoms, leading to impaired functioning, reduced quality of life, and high healthcare and economic costs.
Disruption of calcium–phosphate homeostasis is associated with kidney complications, including hypercalciuria, nephrolithiasis, nephrocalcinosis, and chronic kidney disease.
Parathyroid hormone deficiency leads to reduced bone remodeling and abnormalities in bone mineral density and microarchitecture.
Chronic hypoparathyroidism does not protect against bone loss, as notable proportions of low bone density and osteoporosis have been reported in postmenopausal women, men aged at least 50 years, and young patients with a genetic form of chronic hypoparathyroidism.
Increased risk of vertebral fracture was reported in chronic hypoparathyroidism, including in postmenopausal women and patients with nonsurgical chronic hypoparathyroidism.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(26)00070-6
