IL-1β+ macrophages and the control of pathogenic inflammation in cancer
Interleukin (IL)-1β+ tumor-associated macrophages (TAMs) with a distinct inflammatory gene expression program are recurrently identified across human cancers and linked to poor patient prognosis.
IL-1β+ TAMs originate largely from infiltrating monocytes, and share developmental and functional connections with pro-angiogenic and hypoxia-associated SPP1+ TAMs.
IL-1β+ TAMs are central elements, and possibly organizers, of pathogenic inflammatory niches in the tumor microenvironment (TME), together with subsets of tumor, stromal, and immune cells.
IL-1β+ TAMs engage in long-range interactions with cells in the bone marrow, influencing hematopoiesis and systemic immunity throughout disease initiation, evolution, and therapy.
IL-1β+ TAMs are key drivers of pathogenic inflammation in cancer, and they represent targets for disease prevention, interception, and therapeutic intervention.
https://www.cell.com/trends/immunology/fulltext/S1471-4906(25)00059-6
